1ala: Difference between revisions

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-[[Image:1ala.jpg|left|200px]]
- {{Structure
+==STRUCTURE OF CHICKEN ANNEXIN V AT 2.25-ANGSTROMS RESOLUTION==
-|PDB= 1ala |SIZE=350|CAPTION= <scene name='initialview01'>1ala</scene>, resolution 2.25&Aring;
+<StructureSection load='1ala' size='340' side='right'caption='[[1ala]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
+<table><tr><td colspan='2'>[[1ala]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ALA FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ala FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ala OCA], [https://pdbe.org/1ala PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ala RCSB], [https://www.ebi.ac.uk/pdbsum/1ala PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ala ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ala FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ala OCA], [http://www.ebi.ac.uk/pdbsum/1ala PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ala RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/ANXA5_CHICK ANXA5_CHICK] Collagen-binding protein.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/al/1ala_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ala ConSurf].
+<div style="clear:both"></div>
-'''STRUCTURE OF CHICKEN ANNEXIN V AT 2.25-ANGSTROMS RESOLUTION'''
+==See Also==
+*[[Annexin 3D structures|Annexin 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 A. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.
-==About this Structure==
-ALA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALA OCA].
-==Reference==
-Structure of chicken annexin V at 2.25-A resolution., Bewley MC, Boustead CM, Walker JH, Waller DA, Huber R, Biochemistry. 1993 Apr 20;32(15):3923-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8471604 8471604]
 [[Category: Gallus gallus]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Bewley, M C.]]
+[[Category: Bewley MC]]
-[[Category: Huber, R.]]
+[[Category: Huber R]]
-[[Category: Waller, D A.]]
+[[Category: Waller DA]]
-[[Category: calcium/phospholipid-binding protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:42:41 2008''