5egb: Difference between revisions
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==Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence II== | |||
<StructureSection load='5egb' size='340' side='right'caption='[[5egb]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5egb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EGB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.977Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5egb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5egb OCA], [https://pdbe.org/5egb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5egb RCSB], [https://www.ebi.ac.uk/pdbsum/5egb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5egb ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity). | |||
==See Also== | |||
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Horton | [[Category: Large Structures]] | ||
[[Category: | [[Category: Cheng X]] | ||
[[Category: | [[Category: Horton JR]] | ||
[[Category: | [[Category: Patel A]] | ||
[[Category: Wilson GG]] | |||
[[Category: Zhang X]] | |||
Latest revision as of 15:28, 6 March 2024
Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence IIHuman PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence II
Structural highlights
FunctionPRDM9_HUMAN Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity). See Also |
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