197d: Difference between revisions

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[[Image:197d.gif|left|200px]]


{{Structure
==ORTHORHOMBIC CRYSTAL STRUCTURE OF THE A-DNA OCTAMER D(GTACGTAC). COMPARISON WITH THE TETRAGONAL STRUCTURE==
|PDB= 197d |SIZE=350|CAPTION= <scene name='initialview01'>197d</scene>, resolution 2.190&Aring;
<StructureSection load='197d' size='340' side='right'caption='[[197d]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
<table><tr><td colspan='2'>[[197d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=197D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=197D FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
|GENE=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=197d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=197d OCA], [https://pdbe.org/197d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=197d RCSB], [https://www.ebi.ac.uk/pdbsum/197d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=197d ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=
__TOC__
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=197d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=197d OCA], [http://www.ebi.ac.uk/pdbsum/197d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=197d RCSB]</span>
</StructureSection>
}}
[[Category: Large Structures]]
 
[[Category: Courseille C]]
'''ORTHORHOMBIC CRYSTAL STRUCTURE OF THE A-DNA OCTAMER D(GTACGTAC). COMPARISON WITH THE TETRAGONAL STRUCTURE'''
[[Category: Dautant A]]
 
[[Category: Langlois D'Estaintot B]]
 
[[Category: Precigoux G]]
==Overview==
The X-ray crystal structure of the double-helical A-DNA octanucleotide d(GTACGTAC) has been solved by molecular replacement and refined to a resolution of 0.219 nm. The final R-factor is equal to 16.1% for 1516 observed reflections with F &gt; 4 sigma(F). The sequence crystallizes as an A-DNA-type double helix in the orthorhombic space group P2(1)2(1)2, with one duplex molecule solvated by 66 water molecules in the asymmetric unit. Cell parameters are a = 3.860 nm, b = 5.082 nm, c = 2.174 nm. It is the first time that such a crystal form has been observed. This orthorhombic structure has been compared with the tetragonal structure of the same oligonucleotide. It adopts a bent structure with an unusual packing between symmetry-related molecules.
 
==About this Structure==
197D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=197D OCA].
 
==Reference==
Orthorhombic crystal structure of the A-DNA octamer d(GTACGTAC). Comparison with the tetragonal structure., Langlois d'Estaintot B, Dautant A, Courseille C, Precigoux G, Eur J Biochem. 1993 Apr 15;213(2):673-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8477741 8477741]
[[Category: Protein complex]]
[[Category: Courseille, C.]]
[[Category: Dautant, A.]]
[[Category: Estaintot, B Langlois D.]]
[[Category: Precigoux, G.]]
[[Category: a-dna]]
[[Category: double helix]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:30:09 2008''

Latest revision as of 09:26, 7 February 2024

ORTHORHOMBIC CRYSTAL STRUCTURE OF THE A-DNA OCTAMER D(GTACGTAC). COMPARISON WITH THE TETRAGONAL STRUCTUREORTHORHOMBIC CRYSTAL STRUCTURE OF THE A-DNA OCTAMER D(GTACGTAC). COMPARISON WITH THE TETRAGONAL STRUCTURE

Structural highlights

197d is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.19Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

197d, resolution 2.19Å

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