Beta-phosphoglucomutase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='1lvh' size='340' side='right' caption='Structure of phosphorylated β-phosphoglucomutase complex with Mg+2 ion (PDB code [[1lvh]]).' scene=''>
+<StructureSection load='1lvh' size='350' side='right' caption='Structure of phosphorylated β-phosphoglucomutase complex with Mg+2 ion (PDB code [[1lvh]]).' scene='59/595758/Cv/14'>
 == Function ==
 '''Beta-phosphoglucomutase''' (BPGM) catalyzes the conversion of β-D-glucose 1-phosphate to β-D-glucose 6-phosphate.  Mg+2 ion is the cofactor of the reaction and BPGM activation is achieved by Asp8 phosphorylation (D8P).  α-D-galactose-1-phosphate is an inhibitor of BPGM.  BPGM participates in sugar and starch metabolism.
-== Disease ==
-== Relevance ==
 == Structural highlights ==
-BPGM structure shows the enzyme having 2 domains.  A helical cap domain and an α/β core domain.  The active site is located in the core domain and contains a phosphorylated Asp residue and the octahedral coordinated Mg+2 ion.
+BPGM structure shows the enzyme having <scene name='59/595758/Cv/9'>2 domains</scene>. A <scene name='59/595758/Cv/10'>helical cap domain</scene> and an <scene name='59/595758/Cv/11'>α/β core domain</scene>. The <scene name='59/595758/Cv/12'>active site</scene> is located in the core domain and contains a <scene name='59/595758/Cv/13'>phosphorylated Asp residue and the octahedral coordinated Mg+2 ion</scene>. <ref>PMID:12081483</ref>
-</StructureSection>
 == 3D Structures of β-phosphoglucomutase ==
+[[Beta-phosphoglucomutase 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*β-phosphoglucomutase
-**[[3nas]] – BPGM – ''Bacillus subtilis''<br />
-**[[4g9b]] – BPGM + Mg – ''Escherichia coli''<br />
-**[[1zol]], [[2whe]] – LlBPGM + Mg – ''Lactococcus lactis''<br />
-**[[3fm9]] – LlBPGM (mutant) + Mg <br />
-**[[2wfa]] – LlBPGM + BeF3 + Mg <br />
-**[[1lvh]] – LlBPGM + D8P + Mg <br />
-**[[3dv9]] – BPGM + Mg – ''Bacterioides vulgatus''<br />
-**[[4gib]] – BPGM – ''Clostridium difficile''<br />
-**[[4uw9]] – BPGM + Mg – ''Pyrococcusus''<br />
-*β-phosphoglucomutase complex with glucophosphate derivatives
-**[[1o03]], [[1o08]] – LlBPGM + α-D-glucose 1,6-bisphosphate + Mg <br />
-**[[1z4n]], [[1z4o]] – LlBPGM + α-D-galactose-1-phosphate + Mg <br />
-**[[2wf5]] – LlBPGM + β-D-glucose-6-phosphate + MgF3 + Mg <br />
-**[[3zi4]] – LlBPGM + β-D-glucose-6-phosphate + ScF4 + Mg <br />
-**[[2wf6]] – LlBPGM + β-D-glucose-6-phosphate + AlF4 + Mg <br />
-**[[2wf7]] – LlBPGM + dideoxy-phosphono-β-D-gluco-heptopyranose + AlF4 + Mg <br />
-**[[4c4r]], [[4c4s]] – LlBPGM + β-phosphonomethylene-D-glucopyranose derivative + MgF3 + Mg <br />
-**[[4c4t]] – LlBPGM + β-phosphonomethylene-D-glucopyranose derivative + AlF4 + Mg <br />
-**[[2wf8]] – LlBPGM + β-D-glucose-6-phosphate + α-D-glucose-1-phosphate + BeF3 + Mg <br />
-**[[2wf9]] – LlBPGM + β-D-glucose-6-phosphate + α-D-glucose-6-phosphate + BeF3 + Mg <br />
-}}
 == References ==