3bt1: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:3bt1.jpg|left|200px]]
- {{Structure
+==Structure of urokinase receptor, urokinase and vitronectin complex==
-|PDB= 3bt1 |SIZE=350|CAPTION= <scene name='initialview01'>3bt1</scene>, resolution 2.80&Aring;
+<StructureSection load='3bt1' size='340' side='right'caption='[[3bt1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+U+1052'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+U+1172'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Residue+U+1200'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+U+1201'>AC4</scene> and <scene name='pdbsite=AC5:Man+Binding+Site+For+Residue+U+1202'>AC5</scene>
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+<table><tr><td colspan='2'>[[3bt1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BT1 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-|GENE= PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VTN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PLAUR, MO3, UPAR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00108 KR], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00117 LU], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00134 LU], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01033 Somatomedin_B]</span>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bt1 OCA], [https://pdbe.org/3bt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bt1 RCSB], [https://www.ebi.ac.uk/pdbsum/3bt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bt1 ProSAT]</span></td></tr>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bt1 OCA], [http://www.ebi.ac.uk/pdbsum/3bt1 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=3bt1 RCSB]</span>
+</table>
-}}
+== Disease ==
+[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/3bt1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bt1 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.
-'''Structure of urokinase receptor, urokinase and vitronectin complex'''
+Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes.,Huai Q, Zhou A, Lin L, Mazar AP, Parry GC, Callahan J, Shaw DE, Furie B, Furie BC, Huang M Nat Struct Mol Biol. 2008 Apr;15(4):422-3. Epub 2008 Mar 23. PMID:18376415<ref>PMID:18376415</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3bt1" style="background-color:#fffaf0;"></div>
-==Disease==
+==See Also==
-Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191840 191840]]
+*[[Urokinase 3D Structures|Urokinase 3D Structures]]
+*[[Urokinase plasminogen activator surface receptor 3D structures|Urokinase plasminogen activator surface receptor 3D structures]]
-==About this Structure==
+== References ==
-BT1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BT1 OCA].
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Huang, M.]]
+[[Category: Huang M]]
-[[Category: alternative splicing]]
-[[Category: blood coagulation]]
-[[Category: cell adhesion]]
-[[Category: egf-like domain]]
-[[Category: fibrinolysis]]
-[[Category: glycoprotein]]
-[[Category: gpi-anchor]]
-[[Category: heparin-binding]]
-[[Category: hydrolase]]
-[[Category: immune system]]
-[[Category: immunoglobulin domain]]
-[[Category: kringle]]
-[[Category: lipoprotein]]
-[[Category: membrane]]
-[[Category: pharmaceutical]]
-[[Category: phosphoprotein]]
-[[Category: plasminogen activation]]
-[[Category: polymorphism]]
-[[Category: protease]]
-[[Category: protein-protein complex]]
-[[Category: receptor]]
-[[Category: secreted]]
-[[Category: serine protease]]
-[[Category: sulfation]]
-[[Category: zymogen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 09:56:38 2008''