2rl2: Difference between revisions

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New page: left|200px {{Structure |PDB= 2rl2 |SIZE=350|CAPTION= <scene name='initialview01'>2rl2</scene>, resolution 2.300Å |SITE= <scene name='pdbsite=AC1:So4+Binding+Site...
 
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[[Image:2rl2.jpg|left|200px]]


{{Structure
==Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycin==
|PDB= 2rl2 |SIZE=350|CAPTION= <scene name='initialview01'>2rl2</scene>, resolution 2.300&Aring;
<StructureSection load='2rl2' size='340' side='right'caption='[[2rl2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+713'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+714'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+A+715'>AC3</scene>, <scene name='pdbsite=AC4:Gg6+Binding+Site+For+Residue+A+425'>AC4</scene> and <scene name='pdbsite=AC5:Ud1+Binding+Site+For+Residue+A+712'>AC5</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene>
<table><tr><td colspan='2'>[[2rl2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RL2 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylglucosamine_1-carboxyvinyltransferase UDP-N-acetylglucosamine 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.7 2.5.1.7] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE= MurA or MurZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GG6:[(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC+ACID'>GG6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK09369 PRK09369], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01555 UdpNAET]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rl2 OCA], [https://pdbe.org/2rl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rl2 RCSB], [https://www.ebi.ac.uk/pdbsum/2rl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rl2 ProSAT]</span></td></tr>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rl2 OCA], [http://www.ebi.ac.uk/pdbsum/2rl2 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2rl2 RCSB]</span>
</table>
}}
== Function ==
[https://www.uniprot.org/uniprot/MURA_HAEIN MURA_HAEIN] Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rl/2rl2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rl2 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycin'''
==See Also==
 
*[[Enoylpyruvate transferase 3D structures|Enoylpyruvate transferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2RL2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RL2 OCA].
 
==Reference==
Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycin., Yoon HJ, Lee SJ, Mikami B, Park HJ, Yoo J, Suh SW, Proteins. 2008 Feb 4;71(2):1032-1037. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18247346 18247346]
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: UDP-N-acetylglucosamine 1-carboxyvinyltransferase]]
[[Category: Suh SW]]
[[Category: Suh, S W.]]
[[Category: Yoon HJ]]
[[Category: Yoon, H J.]]
[[Category: cell cycle]]
[[Category: cell division]]
[[Category: cell shape]]
[[Category: cell wall biogenesis/degradation]]
[[Category: cytoplasm]]
[[Category: fosfomycin]]
[[Category: mura]]
[[Category: murz]]
[[Category: peptidoglycan synthesis]]
[[Category: transferase]]
[[Category: udp-n-acetylglucosamine]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 09:53:49 2008''

Latest revision as of 08:30, 17 October 2024

Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycinCrystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycin

Structural highlights

2rl2 is a 1 chain structure with sequence from Haemophilus influenzae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MURA_HAEIN Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2rl2, resolution 2.30Å

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