2qnk: Difference between revisions

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-[[Image:2qnk.jpg|left|200px]]
- {{Structure
+==Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase==
-|PDB= 2qnk |SIZE=350|CAPTION= <scene name='initialview01'>2qnk</scene>, resolution 1.60&Aring;
+<StructureSection load='2qnk' size='340' side='right'caption='[[2qnk]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
+<table><tr><td colspan='2'>[[2qnk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QNK FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyanthranilate_3,4-dioxygenase 3-hydroxyanthranilate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.6 1.13.11.6] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-|GENE= HAAO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam06052 3-HAO]</span>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qnk OCA], [https://pdbe.org/2qnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qnk RCSB], [https://www.ebi.ac.uk/pdbsum/2qnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qnk ProSAT], [https://www.topsan.org/Proteins/CESG/2qnk TOPSAN]</span></td></tr>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qnk OCA], [http://www.ebi.ac.uk/pdbsum/2qnk PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2qnk RCSB]</span>
+</table>
-}}
+== Function ==
+[https://www.uniprot.org/uniprot/3HAO_HUMAN 3HAO_HUMAN] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.<ref>PMID:7514594</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/2qnk_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qnk ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase'''
+==See Also==
+*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-QNK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNK OCA].
+__TOC__
-[[Category: 3-hydroxyanthranilate 3,4-dioxygenase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Bingman, C A.]]
+[[Category: Bingman CA]]
-[[Category: Bitto, E.]]
+[[Category: Bitto E]]
-[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
+[[Category: Phillips Jr GN]]
-[[Category: Jr., G N.Phillips.]]
+[[Category: Wesenberg GE]]
-[[Category: Wesenberg, G E.]]
-[[Category: bicupin fold]]
-[[Category: center for eukaryotic structural genomic]]
-[[Category: cesg]]
-[[Category: cupin barrel]]
-[[Category: extradiol dioxygenase]]
-[[Category: kynurenine pathway]]
-[[Category: metalloenzyme]]
-[[Category: nad+ synthesis]]
-[[Category: oxidoreductase]]
-[[Category: protein structure initiative]]
-[[Category: psi]]
-[[Category: quinolinate]]
-[[Category: structural genomics medical relevance]]
-[[Category: trytophan catabolism]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:43:33 2008''