2iq1: Difference between revisions

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[[Image:2iq1.gif|left|200px]]


{{Structure
==Crystal structure of human PPM1K==
|PDB= 2iq1 |SIZE=350|CAPTION= <scene name='initialview01'>2iq1</scene>, resolution 2.250&Aring;
<StructureSection load='2iq1' size='340' side='right'caption='[[2iq1]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
<table><tr><td colspan='2'>[[2iq1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
|GENE= DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00143 PP2Cc]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [https://pdbe.org/2iq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [https://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iq1 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [http://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB]</span>
</table>
}}
== Disease ==
[https://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN] Intermediate maple syrup urine disease.
== Function ==
[https://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.<ref>PMID:17374715</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/2iq1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iq1 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of human PPM1K'''
==See Also==
 
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2IQ1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Adams, J.]]
[[Category: Adams J]]
[[Category: Almo, S C.]]
[[Category: Almo SC]]
[[Category: Bain, K T.]]
[[Category: Bain KT]]
[[Category: Bonanno, J B.]]
[[Category: Bonanno JB]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: Freeman, J.]]
[[Category: Freeman J]]
[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
[[Category: Pelletier L]]
[[Category: Pelletier, L.]]
[[Category: Russell M]]
[[Category: Russell, M.]]
[[Category: Sauder JM]]
[[Category: Sauder, J M.]]
[[Category: Wasserman S]]
[[Category: Wasserman, S.]]
[[Category: new york structural genomix research consortium]]
[[Category: nysgxrc]]
[[Category: protein phosphatase 2c kappa]]
[[Category: protein structure initiative]]
[[Category: psi-2]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:32:44 2008''

Latest revision as of 12:03, 21 February 2024

Crystal structure of human PPM1KCrystal structure of human PPM1K

Structural highlights

2iq1 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.25Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Disease

PPM1K_HUMAN Intermediate maple syrup urine disease.

Function

PPM1K_HUMAN Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 2007 Apr 1;21(7):784-96. Epub 2007 Mar 20. PMID:17374715 doi:http://dx.doi.org/10.1101/gad.1499107

2iq1, resolution 2.25Å

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