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[[Image:2if2.gif|left|200px]]


{{Structure
==Crystal Structure of the Putative Dephospho-CoA Kinase from Aquifex aeolicus, Northeast Structural Genomics Target QR72.==
|PDB= 2if2 |SIZE=350|CAPTION= <scene name='initialview01'>2if2</scene>, resolution 3.00&Aring;
<StructureSection load='2if2' size='340' side='right'caption='[[2if2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[2if2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IF2 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dephospho-CoA_kinase Dephospho-CoA kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.24 2.7.1.24] </span>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|GENE= coaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02022 DPCK]</span>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">coaE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2if2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2if2 OCA], [http://www.ebi.ac.uk/pdbsum/2if2 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2if2 RCSB]</span>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dephospho-CoA_kinase Dephospho-CoA kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.24 2.7.1.24] </span></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2if2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2if2 OCA], [https://pdbe.org/2if2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2if2 RCSB], [https://www.ebi.ac.uk/pdbsum/2if2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2if2 ProSAT], [https://www.topsan.org/Proteins/NESGC/2if2 TOPSAN]</span></td></tr>
 
</table>
'''Crystal Structure of the Putative Dephospho-CoA Kinase from Aquifex aeolicus, Northeast Structural Genomics Target QR72.'''
== Function ==
 
[[https://www.uniprot.org/uniprot/COAE_AQUAE COAE_AQUAE]] Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity).  
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2IF2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF2 OCA].  
Check<jmol>
[[Category: Aquifex aeolicus]]
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/2if2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2if2 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Aquae]]
[[Category: Dephospho-CoA kinase]]
[[Category: Dephospho-CoA kinase]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Acton, T B.]]
[[Category: Acton, T B]]
[[Category: Baran, M.]]
[[Category: Baran, M]]
[[Category: Cunningham, K.]]
[[Category: Cunningham, K]]
[[Category: Fang, Y.]]
[[Category: Fang, Y]]
[[Category: Forouhar, F.]]
[[Category: Forouhar, F]]
[[Category: Hunt, J F.]]
[[Category: Hunt, J F]]
[[Category: Hussain, A.]]
[[Category: Hussain, A]]
[[Category: Hussain, M.]]
[[Category: Hussain, M]]
[[Category: Liu, J.]]
[[Category: Liu, J]]
[[Category: Ma, L C.]]
[[Category: Ma, L C]]
[[Category: Montelione, G T.]]
[[Category: Montelione, G T]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Rost, B.]]
[[Category: Rost, B]]
[[Category: Seetharaman, J.]]
[[Category: Seetharaman, J]]
[[Category: Tong, L.]]
[[Category: Tong, L]]
[[Category: Wu, M.]]
[[Category: Wu, M]]
[[Category: Xiao, R.]]
[[Category: Xiao, R]]
[[Category: alpha-beta protein]]
[[Category: Alpha-beta protein]]
[[Category: nesg]]
[[Category: Nesg]]
[[Category: northeast structural genomics consortium]]
[[Category: PSI, Protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: Transferase]]
[[Category: psi-2]]
[[Category: structural genomic]]
 
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