Beta-secretase 1: Difference between revisions
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<StructureSection load='4ivt' size='340' side='right' caption='The best structure for Beta-secretase 1 shown: [[4ivt]]' scene=''> | <StructureSection load='4ivt' size='340' side='right' caption='The best structure for Beta-secretase 1 shown: [[4ivt]]' scene=''> | ||
Best example is PDB entry [[4ivt]] and is shown in the viewer.<br> | Best example is PDB entry [[4ivt]] and is shown in the viewer.<br> | ||
== Function == | == Function == | ||
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.Data source: Uniprot [http://www.uniprot.org/uniprot/P56817 P56817]<br> | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.Data source: Uniprot [http://www.uniprot.org/uniprot/P56817 P56817]<br> | ||
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Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.Data source: Uniprot [http://www.uniprot.org/uniprot/P56817 P56817]<br> | Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.Data source: Uniprot [http://www.uniprot.org/uniprot/P56817 P56817]<br> | ||
== Biological process == | == Biological process == | ||
Is involved in the following biological processes:<br> | Is involved in the following biological processes:<br> | ||
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***Title: Crystal structure of BACE1 with its inhibitor | ***Title: Crystal structure of BACE1 with its inhibitor | ||
***1.6 A resolution | ***1.6 A resolution | ||
***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific_name:%22Homo%20sapiens%22&all_molecule_names:%22Beta-secretase%201%22&!chimera:y Search for | ***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific_name:%22Homo%20sapiens%22&all_molecule_names:%22Beta-secretase%201%22&!chimera:y Search the PDB for Beta-secretase 1 from Homo sapiens] | ||
== 3D structure of beta-secretase == | |||
See [[Beta-secretase]] | |||
== Alternative names for Beta-secretase 1 == | |||
Molecule Beta-secretase 1, also known as Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Aspartyl protease 2, Asp 2, ASP2, Memapsin-2, Beta-secretase 1 and Beta-site APP cleaving enzyme 1. | |||
[[Category:Topic Page]][[Category:PDBe]] | [[Category:Topic Page]][[Category:PDBe]] | ||