2jsc: Difference between revisions
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==NMR structure of the cadmium metal-sensor CMTR from Mycobacterium tuberculosis== | ==NMR structure of the cadmium metal-sensor CMTR from Mycobacterium tuberculosis== | ||
<StructureSection load='2jsc' size='340' side='right' caption='[[2jsc | <StructureSection load='2jsc' size='340' side='right'caption='[[2jsc]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jsc]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2jsc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSC FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsc OCA], [https://pdbe.org/2jsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsc RCSB], [https://www.ebi.ac.uk/pdbsum/2jsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CMTR_MYCTU CMTR_MYCTU] Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA.<ref>PMID:12939264</ref> <ref>PMID:15966722</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsc_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsc_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jsc ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Banci | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Bertini | [[Category: Banci L]] | ||
[[Category: Cantini | [[Category: Bertini I]] | ||
[[Category: Cavet | [[Category: Cantini F]] | ||
[[Category: Ciofi-Baffoni | [[Category: Cavet JS]] | ||
[[Category: Dennison | [[Category: Ciofi-Baffoni S]] | ||
[[Category: Graham | [[Category: Dennison C]] | ||
[[Category: Harvie | [[Category: Graham AI]] | ||
[[Category: Robinson | [[Category: Harvie DR]] | ||
[[Category: Robinson NJ]] | |||