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==Solution structure of the Omsk Hemhorraghic Fever Envelope Protein Domain III==
==Solution structure of the Omsk Hemhorraghic Fever Envelope Protein Domain III==
<StructureSection load='1z3r' size='340' side='right' caption='[[1z3r]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='1z3r' size='340' side='right'caption='[[1z3r]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1z3r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Omsk_haemorrhagic_fever_virus Omsk haemorrhagic fever virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z3R FirstGlance]. <br>
<table><tr><td colspan='2'>[[1z3r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Omsk_hemorrhagic_fever_virus Omsk hemorrhagic fever virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3R FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3r OCA], [http://pdbe.org/1z3r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z3r RCSB], [http://www.ebi.ac.uk/pdbsum/1z3r PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3r OCA], [https://pdbe.org/1z3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3r RCSB], [https://www.ebi.ac.uk/pdbsum/1z3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q80J38_9FLAV Q80J38_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]  
[https://www.uniprot.org/uniprot/Q80J37_OHFV Q80J37_OHFV]  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3r_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3r_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3r ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Omsk haemorrhagic fever virus]]
[[Category: Large Structures]]
[[Category: Barrett, A D]]
[[Category: Omsk hemorrhagic fever virus]]
[[Category: Beasley, D W]]
[[Category: Barrett AD]]
[[Category: Chavez, L]]
[[Category: Beasley DW]]
[[Category: Gorenstein, D G]]
[[Category: Chavez L]]
[[Category: Volk, D E]]
[[Category: Gorenstein DG]]
[[Category: Envelope protein]]
[[Category: Volk DE]]
[[Category: Flavivirus domain iii]]
[[Category: Ohf]]
[[Category: Omsk hemorrhagic fever]]
[[Category: Viral protein]]

Latest revision as of 03:43, 21 November 2024

Solution structure of the Omsk Hemhorraghic Fever Envelope Protein Domain IIISolution structure of the Omsk Hemhorraghic Fever Envelope Protein Domain III

Structural highlights

1z3r is a 1 chain structure with sequence from Omsk hemorrhagic fever virus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 15 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q80J37_OHFV

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

We have solved the NMR solution structure of domain III from the Omsk hemorrhagic fever virus envelope protein and report the first sequencing of the Guriev strain of this virus. Important structural differences between tick-borne flaviviruses, such as OHFV and TBE, and mosquito-borne flaviviruses, such as West Nile virus, are discussed.

Structure of the envelope protein domain III of Omsk hemorrhagic fever virus.,Volk DE, Chavez L, Beasley DW, Barrett AD, Holbrook MR, Gorenstein DG Virology. 2006 Jul 20;351(1):188-95. Epub 2006 May 2. PMID:16647096[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. Volk DE, Chavez L, Beasley DW, Barrett AD, Holbrook MR, Gorenstein DG. Structure of the envelope protein domain III of Omsk hemorrhagic fever virus. Virology. 2006 Jul 20;351(1):188-95. Epub 2006 May 2. PMID:16647096 doi:10.1016/j.virol.2006.03.030
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