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==Structural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome==
==Structural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome==
<StructureSection load='2ftc' size='340' side='right' caption='[[2ftc]], [[Resolution|resolution]] 12.10&Aring;' scene=''>
<SX load='2ftc' size='340' side='right' viewer='molstar' caption='[[2ftc]], [[Resolution|resolution]] 12.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ftc]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FTC FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ftc]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FTC FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ftc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftc OCA], [http://pdbe.org/2ftc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ftc RCSB], [http://www.ebi.ac.uk/pdbsum/2ftc PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 12.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ftc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftc OCA], [https://pdbe.org/2ftc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ftc RCSB], [https://www.ebi.ac.uk/pdbsum/2ftc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ftc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RM01_BOVIN RM01_BOVIN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ftc_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ft/2ftc_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ftc ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Protein translation is essential for all forms of life and is conducted by a macromolecular complex, the ribosome. Evolutionary changes in protein and RNA sequences can affect the 3D organization of structural features in ribosomes in different species. The most dramatic changes occur in animal mitochondria, whose genomes have been reduced and altered significantly. The RNA component of the mitochondrial ribosome (mitoribosome) is reduced in size, with a compensatory increase in protein content. Until recently, it was unclear how these changes affect the 3D structure of the mitoribosome. Here, we present a structural model of the large subunit of the mammalian mitoribosome developed by combining molecular modeling techniques with cryo-electron microscopic data at 12.1A resolution. The model contains 93% of the mitochondrial rRNA sequence and 16 mitochondrial ribosomal proteins in the large subunit of the mitoribosome. Despite the smaller mitochondrial rRNA, the spatial positions of RNA domains known to be involved directly in protein synthesis are essentially the same as in bacterial and archaeal ribosomes. However, the dramatic reduction in rRNA content necessitates evolution of unique structural features to maintain connectivity between RNA domains. The smaller rRNA sequence also limits the likelihood of tRNA binding at the E-site of the mitoribosome, and correlates with the reduced size of D-loops and T-loops in some animal mitochondrial tRNAs, suggesting co-evolution of mitochondrial rRNA and tRNA structures.
A structural model for the large subunit of the mammalian mitochondrial ribosome.,Mears JA, Sharma MR, Gutell RR, McCook AS, Richardson PE, Caulfield TR, Agrawal RK, Harvey SC J Mol Biol. 2006 Apr 21;358(1):193-212. Epub 2006 Feb 10. PMID:16510155<ref>PMID:16510155</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2ftc" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Ribosomal protein L13|Ribosomal protein L13]]
*[[Ribosomal protein L13|Ribosomal protein L13]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Agrawal, R K]]
[[Category: Large Structures]]
[[Category: Gutell, R R]]
[[Category: Agrawal RK]]
[[Category: Harvey, S C]]
[[Category: Gutell RR]]
[[Category: Mears, J A]]
[[Category: Harvey SC]]
[[Category: Richardson, P E]]
[[Category: Mears JA]]
[[Category: Sharma, M R]]
[[Category: Richardson PE]]
[[Category: Large ribosomal subunit]]
[[Category: Sharma MR]]
[[Category: Mitochondrial ribosome]]
[[Category: Ribosomal rna]]
[[Category: Ribosome]]

Latest revision as of 12:25, 14 February 2024

Structural Model for the Large Subunit of the Mammalian Mitochondrial RibosomeStructural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome

2ftc, resolution 12.10Å

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