2hg1: Difference between revisions

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-[[Image:2hg1.jpg|left|200px]]
- {{Structure
+==N-Domain Of Grp94 In Complex With the Novel Ligand N-(2-hydroxyl)ethyl Carboxyamido Adenosine==
-|PDB= 2hg1 |SIZE=350|CAPTION= <scene name='initialview01'>2hg1</scene>, resolution 2.30&Aring;
+<StructureSection load='2hg1' size='340' side='right'caption='[[2hg1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=MO6:MAGNESIUM+ION,+6+WATERS+COORDINATED'>MO6</scene>, <scene name='pdbligand=N5O:5&#39;-N-(2-HYDROXYL)ETHYL+CARBOXYAMIDO+ADENOSINE'>N5O</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene> and <scene name='pdbligand=1PE:PENTAETHYLENE GLYCOL'>1PE</scene>
+<table><tr><td colspan='2'>[[2hg1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HG1 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-|GENE= HSP90B1, TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 Canis lupus familiaris])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N5O:5-N-(2-HYDROXYL)ETHYL+CARBOXYAMIDO+ADENOSINE'>N5O</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hg1 OCA], [https://pdbe.org/2hg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hg1 RCSB], [https://www.ebi.ac.uk/pdbsum/2hg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hg1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/2hg1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hg1 ConSurf].
+<div style="clear:both"></div>
-'''N-Domain Of Grp94 In Complex With the Novel Ligand N-(2-hydroxyl)ethyl Carboxyamido Adenosine'''
+==See Also==
+*[[Heat Shock Protein structures|Heat Shock Protein structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-HG1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HG1 OCA].
 [[Category: Canis lupus familiaris]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Gewirth, D T.]]
+[[Category: Gewirth DT]]
-[[Category: Immormino, R M.]]
+[[Category: Immormino RM]]
-[[Category: 1PE]]
-[[Category: MO6]]
-[[Category: N5O]]
-[[Category: PG4]]
-[[Category: adenosine]]
-[[Category: chaperone]]
-[[Category: grp94]]
-[[Category: hsp82]]
-[[Category: hsp90]]
-[[Category: htpg]]
-[[Category: ligand]]
-[[Category: neaca]]
-[[Category: neca]]
-[[Category: neoca]]
-[[Category: npca]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:15:20 2008''