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[[Image:2dwc.jpg|left|200px]]


{{Structure
==Crystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADP==
|PDB= 2dwc |SIZE=350|CAPTION= <scene name='initialview01'>2dwc</scene>, resolution 1.70&Aring;
<StructureSection load='2dwc' size='340' side='right'caption='[[2dwc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
<table><tr><td colspan='2'>[[2dwc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DWC FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
|GENE= PH0318 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dwc OCA], [https://pdbe.org/2dwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dwc RCSB], [https://www.ebi.ac.uk/pdbsum/2dwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dwc ProSAT], [https://www.topsan.org/Proteins/RSGI/2dwc TOPSAN]</span></td></tr>
 
</table>
'''Crystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADP'''
== Function ==
 
[https://www.uniprot.org/uniprot/PURT_PYRHO PURT_PYRHO] Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP.[HAMAP-Rule:MF_01643]
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2DWC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWC OCA].  
Check<jmol>
[[Category: Pyrococcus horikoshii]]
  <jmolCheckbox>
[[Category: Single protein]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/2dwc_consurf.spt"</scriptWhenChecked>
[[Category: Arai, R.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Kamo-Uchikubo, T.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
  </jmolCheckbox>
[[Category: Shirouzu, M.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dwc ConSurf].
[[Category: Yokoyama, S.]]
<div style="clear:both"></div>
[[Category: Yoshikawa, S.]]
__TOC__
[[Category: ADP]]
</StructureSection>
[[Category: SO4]]
[[Category: Large Structures]]
[[Category: national project on protein structural and functional analyse]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: nppsfa]]
[[Category: Arai R]]
[[Category: phosphoribosylglycinamide formyltransferase]]
[[Category: Kamo-Uchikubo T]]
[[Category: purine ribonucleotide biosynthesis]]
[[Category: Shirouzu M]]
[[Category: purt]]
[[Category: Yokoyama S]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: Yoshikawa S]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 14:58:06 2008''

Latest revision as of 11:31, 25 October 2023

Crystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADPCrystal structure of Probable phosphoribosylglycinamide formyl transferase from Pyrococcus horikoshii OT3 complexed with ADP

Structural highlights

2dwc is a 2 chain structure with sequence from Pyrococcus horikoshii OT3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

PURT_PYRHO Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP.[HAMAP-Rule:MF_01643]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2dwc, resolution 1.70Å

Drag the structure with the mouse to rotate

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