1t2a: Difference between revisions

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-[[Image:1t2a.gif|left|200px]]
- {{Structure
+==Crystal structure of human GDP-D-mannose 4,6-dehydratase==
-|PDB= 1t2a |SIZE=350|CAPTION= <scene name='initialview01'>1t2a</scene>, resolution 1.84&Aring;
+<StructureSection load='1t2a' size='340' side='right'caption='[[1t2a]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
+<table><tr><td colspan='2'>[[1t2a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T2A FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/GDP-mannose_4,6-dehydratase GDP-mannose 4,6-dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.47 4.2.1.47]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
-|GENE= GMDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2a OCA], [https://pdbe.org/1t2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t2a RCSB], [https://www.ebi.ac.uk/pdbsum/1t2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2a ProSAT]</span></td></tr>
+</table>
-'''Crystal structure of human GDP-D-mannose 4,6-dehydratase'''
+== Function ==
+[https://www.uniprot.org/uniprot/GMDS_HUMAN GMDS_HUMAN] Conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose.
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-T2A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2A OCA].
+Check<jmol>
-[[Category: GDP-mannose 4,6-dehydratase]]
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t2/1t2a_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t2a ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Houston, S.]]
+[[Category: Houston S]]
-[[Category: Loppnau, P.]]
+[[Category: Loppnau P]]
-[[Category: Oppermann, U.]]
+[[Category: Oppermann U]]
-[[Category: Sharma, S.]]
+[[Category: Sharma S]]
-[[Category: Sundstrom, M.]]
+[[Category: Sundstrom M]]
-[[Category: Vedadi, M.]]
+[[Category: Vedadi M]]
-[[Category: Walker, J R.]]
+[[Category: Walker JR]]
-[[Category: Wasney, G.]]
+[[Category: Wasney G]]
-[[Category: GDP]]
-[[Category: NDP]]
-[[Category: rossman-fold]]
-[[Category: sdr]]
-[[Category: short-chain dehydrogenase/reductase]]
-[[Category: structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 13:40:59 2008''