2pxx: Difference between revisions

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==Human putative methyltransferase MGC2408==
==Human putative methyltransferase MGC2408==
<StructureSection load='2pxx' size='340' side='right' caption='[[2pxx]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='2pxx' size='340' side='right'caption='[[2pxx]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2pxx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PXX FirstGlance]. <br>
<table><tr><td colspan='2'>[[2pxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PXX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGC2408 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxx OCA], [http://pdbe.org/2pxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pxx RCSB], [http://www.ebi.ac.uk/pdbsum/2pxx PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxx OCA], [https://pdbe.org/2pxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pxx RCSB], [https://www.ebi.ac.uk/pdbsum/2pxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pxx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ECE2_HUMAN ECE2_HUMAN]] Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.<ref>PMID:12560336</ref>
[https://www.uniprot.org/uniprot/EFMT4_HUMAN EFMT4_HUMAN] Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2).<ref>PMID:28520920</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/px/2pxx_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/px/2pxx_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pxx ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bochkarev, A]]
[[Category: Arrowsmith CH]]
[[Category: Dombrovsky, L]]
[[Category: Bochkarev A]]
[[Category: Edwards, A M]]
[[Category: Dombrovsky L]]
[[Category: Loppnau, P]]
[[Category: Edwards AM]]
[[Category: Plotnikov, A N]]
[[Category: Loppnau P]]
[[Category: Structural genomic]]
[[Category: Plotnikov AN]]
[[Category: Sundstrom, M]]
[[Category: Sundstrom M]]
[[Category: Tempel, W]]
[[Category: Tempel W]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Wu, H]]
[[Category: Wu H]]
[[Category: Zeng, H]]
[[Category: Zeng H]]
[[Category: Zhu, H]]
[[Category: Zhu H]]
[[Category: Loc84291]]
[[Category: Methyltransferase]]
[[Category: Mgc2408]]
[[Category: Sgc]]
[[Category: Transferase]]

Latest revision as of 12:12, 21 February 2024

Human putative methyltransferase MGC2408Human putative methyltransferase MGC2408

Structural highlights

2pxx is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

EFMT4_HUMAN Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Jakobsson ME, Malecki J, Nilges BS, Moen A, Leidel SA, Falnes PØ. Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation. Nucleic Acids Res. 2017 Aug 21;45(14):8239-8254. PMID:28520920 doi:10.1093/nar/gkx432

2pxx, resolution 1.30Å

Drag the structure with the mouse to rotate

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