2m8u: Difference between revisions

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 ==Solution structure of the Dictyostelium discodieum Myosin Light Chain, MlcC==
-<StructureSection load='2m8u' size='340' side='right' caption='[[2m8u]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2m8u' size='340' side='right'caption='[[2m8u]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2m8u]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M8U FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2m8u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M8U FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m8u OCA], [http://pdbe.org/2m8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m8u RCSB], [http://www.ebi.ac.uk/pdbsum/2m8u PDBsum]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m8u OCA], [https://pdbe.org/2m8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m8u RCSB], [https://www.ebi.ac.uk/pdbsum/2m8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m8u ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q54HC2_DICDI Q54HC2_DICDI]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Myosin light chains are key regulators of class 1 myosins and typically comprise two domains, with calmodulin being the archetypal example. They bind IQ motifs within the myosin neck region and amplify conformational changes in motor domain. A single lobe light chain, myosin light chain C (MlcC), was recently identified and shown to specifically bind to two sequentially divergent IQ motifs of the Dictyostelium myosin-1C. Towards providing a molecular basis of this interaction, the structures of apo-MlcC and a 2:1 MlcC:myosin-1C neck complex were determined. The two non-functional EF-hand motifs of MlcC pack together to form a globular four-helix bundle that opens up to expose a central hydrophobic groove, which interacts the N-terminal portion of the divergent IQ1 and IQ2 motifs. N- and C-terminal regions of MlcC make critical contacts that contribute to its specific interactions with the myosin-1C divergent IQ motifs; contacts that deviate from the traditional mode of calmodulin-IQ recognition.
+Structure of the single-lobe myosin light chain C in complex with the light chain-binding domains of myosin-1C provides insights into divergent IQ-motif recognition.,Langelaan DN, Liburd J, Yang Y, Miller E, Chitayat S, Crawley SW, Cote GP, Smith SP J Biol Chem. 2016 Jul 27. pii: jbc.M116.746313. PMID:27466369<ref>PMID:27466369</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2m8u" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Chitayat, S]]
+[[Category: Dictyostelium discoideum]]
-[[Category: Cote, G P]]
+[[Category: Large Structures]]
-[[Category: Crawley, S W]]
+[[Category: Chitayat S]]
-[[Category: Langelaan, D]]
+[[Category: Cote GP]]
-[[Category: Liburd, J D]]
+[[Category: Crawley SW]]
-[[Category: Miller, E]]
+[[Category: Langelaan D]]
-[[Category: Smith, S P]]
+[[Category: Liburd JD]]
-[[Category: Contractile protein]]
+[[Category: Miller E]]
-[[Category: Helical bundle]]
+[[Category: Smith SP]]
-[[Category: Myosin light chain]]