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| == Lysozyme ==
| | <StructureSection load='3wja' size='340' side='right' caption='The best structure for NADP-dependent malic enzyme shown: [[3wja]]' scene=''> |
| <StructureSection load='1swy' size='340' side='right' caption='Caption for this structure' scene=''> | | Best example is PDB entry [[3wja]] and is shown in the viewer.<br> |
| Best example is 1swy<br> | | ==Catalytic Activity == |
| Molecule Lysozyme, also known as Lysozyme, CP-7 lysin, Muramidase, Endolysin, 1,4-beta-N-acetylmuramidase, Lysis protein, CP-1 lysin, Lysozyme murein hydrolase, Protein gp17, Transglycosylase, Hevamine-A, Chitinase and L-alanyl-D-glutamate peptidase.
| | Oxaloacetate = pyruvate + CO(2).Data source: Uniprot [http://www.uniprot.org/uniprot/P48163 P48163]<br> |
| == Function == | | Or the decarboxylation of malate to pyruvate<ref>PMID:8187880</ref>. |
| lysozyme activity<br>
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| catalytic activity<br>
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| hydrolase activity<br>
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| hydrolase activity, acting on glycosyl bonds<br>
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| carbon-oxygen lyase activity, acting on polysaccharides<br>
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| lyase activity<br>
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| chitinase activity<br>
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| hydrolase activity, hydrolyzing O-glycosyl compounds<br>
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| sequence-specific DNA binding<br>
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| == Disease ==
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| == Relevance ==
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| == Structural highlights ==
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| == Biological process == | | == Biological process == |
| Is involved in the following biological processes:<br> | | Is involved in the following biological processes:<br> |
| cell wall macromolecule catabolic process<br>
| | malate metabolic process<br> |
| peptidoglycan catabolic process<br>
| | oxidation-reduction process<br> |
| metabolic process<br>
| | response to carbohydrate<br> |
| defense response to bacterium<br>
| | response to hormone<br> |
| cytolysis<br>
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| viral release from host cell<br>
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| carbohydrate metabolic process<br> | | carbohydrate metabolic process<br> |
| chitin catabolic process<br>
| | protein tetramerization<br> |
| polysaccharide catabolic process<br>
| | regulation of NADP metabolic process<br> |
| cytolysis by virus of host cell<br>
| | NADP biosynthetic process<br> |
| cell wall organization<br>
| | small molecule metabolic process<br> |
| | cellular lipid metabolic process<br> |
| == In structures == | | == In structures == |
| Lysozyme is found in 595 PDB entries<br>
| | NADP-dependent malic enzyme is found in 3 PDB entries<br> |
| {{#tree:
| | *<b>Eukaryota</b> (3 PDB entries): <br> |
| *<b>Eukaryota<b> 16 PDB entries | | **<b>Homo sapiens</b> (2 PDB entries): <br> |
| **<b>Homo sapiens</b> 1 PDB entries | | ***[[3wja]] <div class="pdb-prints 3wja"></div> |
| ***[[4uis]]Title: The cryoEM structure of human gamma-Secretase complex
| | ***Title: The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form |
| Experimental EM map [http://pdbe.org/emd-2974 emd-2974]. <br>
| | ***2.548 A resolution |
| 4.4 A resolution
| | ***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific_name:%22Homo%20sapiens%22&all_molecule_names:%22NADP-dependent%20malic%20enzyme%22&!chimera:y Search the PDB for NADP-dependent malic enzyme from Homo sapiens] |
| Other macromolecules also in this entry: GAMMA-SECRETASE, Nicastrin, Presenilin-1 NTF subunit, .
| | **<b>Columba livia</b> (1 PDB entries): <br> |
| **<b>Hevea brasiliensis</b> 7 PDB entries
| | ***[[1gq2]] <div class="pdb-prints 1gq2"></div> |
| ***[[1kqy]]Title: Hevamine Mutant D125A/E127A/Y183F in Complex with Penta-NAG | | ***Title: MALIC ENZYME FROM PIGEON LIVER |
| 1.92 A resolution
| | ***2.5 A resolution |
| | | == Alternative names for NADP-dependent malic enzyme == |
| **<b>Meretrix lusoria</b> 3 PDB entries
| | Molecule '''NADP-dependent malic enzyme''', also known as '''NADP-ME''', '''NADP-dependent malic enzyme''' and '''Malic enzyme 1'''. |
| ***[[4pj2]]Title: Crystal structure of Aeromonas hydrophila PliI in complex with Meretrix lusoria lysozyme | |
| 1.24 A resolution
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| Other macromolecules also in this entry: Putative exported protein, .
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| **<b>Antheraea mylitta</b> 1 PDB entries
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| ***[[1iiz]]Title: Crystal Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antheraea mylitta | |
| 2.4 A resolution | |
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| **<b>Ruditapes philippinarum</b> 1 PDB entries
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| ***[[2dqa]]Title: Crystal Structure of Tapes japonica Lysozyme | |
| 1.6 A resolution
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| **<b>Mus musculus</b> 1 PDB entries
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| ***[[1iak]]Title: HISTOCOMPATIBILITY ANTIGEN I-AK
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| 1.9 A resolution
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| Other macromolecules also in this entry: H-2 class II histocompatibility antigen, A-K beta chain, H-2 class II histocompatibility antigen, A-K alpha chain.
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| **<b>Bombyx mori</b> 2 PDB entries | |
| ***[[1gd6]]Title: STRUCTURE OF THE BOMBYX MORI LYSOZYME
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| 2.5 A resolution
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| *<b>Viruses<b> 578 PDB entries
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| **<b>Enterobacteria phage P22</b> 2 PDB entries
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| ***[[2anv]]Title: crystal structure of P22 lysozyme mutant L86M | |
| 1.04 A resolution
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| **<b>Enterobacteria phage P21</b> 2 PDB entries
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| ***[[3hdf]]Title: Crystal structure of truncated endolysin R21 from phage 21 | |
| 1.7 A resolution
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| **<b>Enterobacteria phage T4</b> 561 PDB entries | |
| ***[[1swy]]Title: Use of a Halide Binding Site to Bypass the 1000-atom Limit to Ab initio Structure Determination | |
| 1.06 A resolution
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| **<b>Escherichia phage T5</b> 1 PDB entries
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| ***[[2mxz]]Title: Bacteriophage T5 l-alanoyl-d-glutamate peptidase comlpex with Zn2+ (Endo T5-ZN2+)
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| N/A A resolution
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| **<b>Enterobacteria phage lambda</b> 3 PDB entries
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| ***[[1am7]]Title: Lysozyme from bacteriophage lambda
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| 2.3 A resolution
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| **<b>Streptococcus phage CP-7</b> 1 PDB entries
| | == 3D Structures of NADP-dependent malic enzyme == |
| ***[[4cvd]]Title: Crystal structure of the central repeat of cell wall binding module of Cpl7
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| 1.666 A resolution
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| **<b>Enterobacteria phage P1</b> 2 PDB entries
| | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} |
| ***[[1xju]]Title: Crystal structure of secreted inactive form of P1 phage endolysin Lyz
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| 1.07 A resolution
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| **<b>Streptococcus phage Cp-1</b> 6 PDB entries
| | [[3wja]], [[2aw5]] – hME - human<br /> |
| ***[[2j8g]]Title: Crystal structure of the modular Cpl-1 endolysin complexed with a peptidoglycan analogue (E94Q mutant in complex with a tetrasaccharide- pentapeptide)
| | [[7x11]], [[7x12]] – hME1 + NADP<br /> |
| 1.69 A resolution
| | [[8e76]], [[8eyn]] – hME3<br /> |
| | [[8e78]], [[8e8o]], [[8eyo]] – hME3 + NADP<br /> |
| | [[1gq2]] – ME + NADP - pigeon<br /> |
| | [[5ou5]] – ME - maize<br /> |
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| *<b>Bacteria<b> 1 PDB entries
| | == References == |
| **<b>Enterobacteria phage T4</b> 1 PDB entries
| | <references/> |
| ***[[2qb0]]Title: Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.
| | [[Category:Topic Page]][[Category:PDBe]] |
| 2.56 A resolution
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| Other macromolecules also in this entry: Transcription factor ETV6, .
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| **<b>Escherichia coli</b> 1 PDB entries
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| ***[[2qb0]]Title: Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.
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| 2.56 A resolution
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| Other macromolecules also in this entry: Transcription factor ETV6, .
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| }}
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