1a8f: Difference between revisions

<StructureSection load='1a8f' size='340' side='right' caption='[[1a8f]], [[Resolution|resolution]] 1.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[1a8f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A8F FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8f OCA], [http://pdbe.org/1a8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a8f RCSB], [http://www.ebi.ac.uk/pdbsum/1a8f PDBsum]</span></td></tr>

[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>

[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.  

     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8f_consurf.spt"</scriptWhenChecked>

     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

*[[Transferrin|Transferrin]]

[[Category: Human]]

[[Category: Anderson, B F]]

[[Category: Baker, E N]]

[[Category: Baker, H]]

[[Category: Bewley, M]]

[[Category: Brayer, G D]]

[[Category: Chen, J]]

[[Category: Luo, Y]]

[[Category: Macgillivray, R T.A]]

[[Category: Mason, A B]]

[[Category: Moore, S A]]

[[Category: Murphy, M E.P]]

[[Category: Smith, C A]]

[[Category: Wang, Y]]

[[Category: Woodworth, R C]]

[[Category: Transferrin]]