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NADP-dependent malic enzyme: Difference between revisions

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== Lysozyme ==
<StructureSection load='3wja' size='340' side='right' caption='The best structure for NADP-dependent malic enzyme shown: [[3wja]]' scene=''>
<StructureSection load='1swy' size='340' side='right' caption='Caption for this structure' scene=''>
Best example is PDB entry [[3wja]] and is shown in the viewer.<br>
Best example is 1swy<br>
==Catalytic Activity ==
Molecule Lysozyme, also known as Lysozyme, CP-7 lysin, Muramidase, Endolysin, 1,4-beta-N-acetylmuramidase, Lysis protein, CP-1 lysin, Lysozyme murein hydrolase, Protein gp17, Transglycosylase, Hevamine-A, Chitinase and L-alanyl-D-glutamate peptidase.
Oxaloacetate = pyruvate + CO(2).Data source: Uniprot [http://www.uniprot.org/uniprot/P48163 P48163]<br>
== Function ==
Or the decarboxylation of malate to pyruvate<ref>PMID:8187880</ref>.
lysozyme activity<br>
catalytic activity<br>
hydrolase activity<br>
hydrolase activity, acting on glycosyl bonds<br>
carbon-oxygen lyase activity, acting on polysaccharides<br>
lyase activity<br>
chitinase activity<br>
hydrolase activity, hydrolyzing O-glycosyl compounds<br>
sequence-specific DNA binding<br>


== Disease ==
== Relevance ==
== Structural highlights ==
== Biological process ==
== Biological process ==
Is involved in the following biological processes:<br>
Is involved in the following biological processes:<br>
cell wall macromolecule catabolic process<br>
malate metabolic process<br>
peptidoglycan catabolic process<br>
oxidation-reduction process<br>
metabolic process<br>
response to carbohydrate<br>
defense response to bacterium<br>
response to hormone<br>
cytolysis<br>
viral release from host cell<br>
carbohydrate metabolic process<br>
carbohydrate metabolic process<br>
chitin catabolic process<br>
protein tetramerization<br>
polysaccharide catabolic process<br>
regulation of NADP metabolic process<br>
cytolysis by virus of host cell<br>
NADP biosynthetic process<br>
cell wall organization<br>
small molecule metabolic process<br>
cellular lipid metabolic process<br>
== In structures ==
== In structures ==
Lysozyme is found in 595 PDB entries<br>
NADP-dependent malic enzyme is found in 3 PDB entries<br>
<br><b>Homo sapiens</b> (1 PDB entries): <br>
*<b>Eukaryota</b> (3 PDB entries): <br>
[[4uis]] <div class="pdb-prints 4uis"></div><br><br>Title: The cryoEM structure of human gamma-Secretase complex<br>
**<b>Homo sapiens</b> (2 PDB entries): <br>
Experimental EM map [http://www.ebi.ac.uk/pdbe/entry/emdb/emd-2974 emd-2974]. <br>
***[[3wja]] <div class="pdb-prints 3wja"></div>
4.4 A resolution <br>
***Title: The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form
Other macromolecules also in this entry: GAMMA-SECRETASE, Nicastrin, Presenilin-1 NTF subunit, . <br><br>
***2.548 A resolution
<br><b>Enterobacteria phage P22</b> (2 PDB entries): <br>
***[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific_name:%22Homo%20sapiens%22&all_molecule_names:%22NADP-dependent%20malic%20enzyme%22&!chimera:y Search the PDB for NADP-dependent malic enzyme from Homo sapiens]
[[2anv]] <div class="pdb-prints 2anv"></div><br><br>Title: crystal structure of P22 lysozyme mutant L86M<br>
**<b>Columba livia</b> (1 PDB entries): <br>
1.04 A resolution <br>
***[[1gq2]] <div class="pdb-prints 1gq2"></div>
<br>
***Title: MALIC ENZYME FROM PIGEON LIVER
[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:\\"Enterobacteria phage P22\\"&molecule_name:\\"Lysozyme\\" Search for other PDB entries]<br><b>Enterobacteria phage P21</b> (2 PDB entries): <br>
***2.5 A resolution
[[3hdf]] <div class="pdb-prints 3hdf"></div><br><br>Title: Crystal structure of truncated endolysin R21 from phage 21<br>
== Alternative names for NADP-dependent malic enzyme ==
1.7 A resolution <br>
Molecule '''NADP-dependent malic enzyme''', also known as '''NADP-ME''', '''NADP-dependent malic enzyme''' and '''Malic enzyme 1'''.
<br>
 
[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:"Enterobacteria phage P21"&molecule_name:"Lysozyme" Search for other PDB entries]<br><b>Hevea brasiliensis</b> (7 PDB entries): <br>
== 3D Structures of NADP-dependent malic enzyme ==
[[1kqy]] <div class="pdb-prints 1kqy"></div><br><br>Title: Hevamine Mutant D125A/E127A/Y183F in Complex with Penta-NAG<br>
 
1.92 A resolution <br>
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
<br>
[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:"Hevea brasiliensis"&molecule_name:"Lysozyme" Search for other PDB entries]<br><b>Escherichia phage T5</b> (1 PDB entries): <br>
 
[[2mxz]] <div class="pdb-prints 2mxz"></div><br><br>Title: Bacteriophage T5 l-alanoyl-d-glutamate peptidase comlpex with Zn2+ (Endo T5-ZN2+)<br>
[[3wja]], [[2aw5]] – hME - human<br />
N/A A resolution <br>
[[7x11]], [[7x12]] – hME1 + NADP<br />
<br>
[[8e76]], [[8eyn]] – hME3<br />
<br><b>Streptococcus phage CP-7</b> (1 PDB entries): <br>
[[8e78]], [[8e8o]], [[8eyo]] – hME3 + NADP<br />
[[4cvd]] <div class="pdb-prints 4cvd"></div><br><br>Title: Crystal structure of the central repeat of cell wall binding module of Cpl7<br>
[[1gq2]] – ME + NADP - pigeon<br />
1.666 A resolution <br>
[[5ou5]] – ME - maize<br />
<br>
 
<br><b>Antheraea mylitta</b> (1 PDB entries): <br>
== References ==
[[1iiz]] <div class="pdb-prints 1iiz"></div><br><br>Title: Crystal Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antheraea mylitta<br>
<references/>
2.4 A resolution <br>
[[Category:Topic Page]][[Category:PDBe]]
<br>
<br><b>Mus musculus</b> (1 PDB entries): <br>
[[1iak]] <div class="pdb-prints 1iak"></div><br><br>Title: HISTOCOMPATIBILITY ANTIGEN I-AK<br>
1.9 A resolution <br>
Other macromolecules also in this entry: H-2 class II histocompatibility antigen, A-K beta chain, H-2 class II histocompatibility antigen, A-K alpha chain. <br><br>
<br><b>Bombyx mori</b> (2 PDB entries): <br>
[[1gd6]] <div class="pdb-prints 1gd6"></div><br><br>Title: STRUCTURE OF THE BOMBYX MORI LYSOZYME<br>
2.5 A resolution <br>
<br>
[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:"Bombyx mori"&molecule_name:"Lysozyme" Search for other PDB entries]<br><b>Streptococcus phage Cp-1</b> (6 PDB entries): <br>
[[2j8g]] <div class="pdb-prints 2j8g"></div><br><br>Title: Crystal structure of the modular Cpl-1 endolysin complexed with a peptidoglycan analogue (E94Q mutant in complex with a tetrasaccharide- pentapeptide)<br>
1.69 A resolution <br>
<br>
[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:"Streptococcus phage Cp-1"&molecule_name:"Lysozyme" Search for other PDB entries]<br><b>Enterobacteria phage T4</b> (562 PDB entries): <br>
[[1swy]] <div class="pdb-prints 1swy"></div><br><br>Title: Use of a Halide Binding Site to Bypass the 1000-atom Limit to Ab initio Structure Determination<br>
1.06 A resolution <br>
<br>
[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:"Enterobacteria phage T4"&molecule_name:"Lysozyme" Search for other PDB entries]<br><b>Enterobacteria phage P1</b> (2 PDB entries): <br>
[[1xju]] <div class="pdb-prints 1xju"></div><br><br>Title: Crystal structure of secreted inactive form of P1 phage endolysin Lyz<br>
1.07 A resolution <br>
<br>
[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:"Enterobacteria phage P1"&molecule_name:"Lysozyme" Search for other PDB entries]<br><b>Enterobacteria phage lambda</b> (3 PDB entries): <br>
[[1am7]] <div class="pdb-prints 1am7"></div><br><br>Title: Lysozyme from bacteriophage lambda<br>
2.3 A resolution <br>
<br>
[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:"Enterobacteria phage lambda"&molecule_name:"Lysozyme" Search for other PDB entries]<br><b>Meretrix lusoria</b> (3 PDB entries): <br>
[[4pj2]] <div class="pdb-prints 4pj2"></div><br><br>Title: Crystal structure of Aeromonas hydrophila PliI in complex with Meretrix lusoria lysozyme<br>  
1.24 A resolution <br>
Other macromolecules also in this entry: Putative exported protein, . <br><br>
[http://www.ebi.ac.uk/pdbe/entry/search/index?organism_scientific:"Meretrix lusoria"&molecule_name:"Lysozyme" Search for other PDB entries]<br><b>Ruditapes philippinarum</b> (1 PDB entries): <br>
[[2dqa]] <div class="pdb-prints 2dqa"></div><br><br>Title: Crystal Structure of Tapes japonica Lysozyme<br>
1.6 A resolution <br>
<br>
<br><b>Escherichia coli</b> (1 PDB entries): <br>
[[2qb0]] <div class="pdb-prints 2qb0"></div><br><br>Title: Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker.<br>
2.56 A resolution <br>
Other macromolecules also in this entry: Transcription factor ETV6, . <br><br>

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