5aa7: Difference between revisions

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-'''Unreleased structure'''
-The entry 5aa7 is ON HOLD  until Paper Publication
+==Structural and functional characterization of a chitin-active 15.5 kDa lytic polysaccharide monooxygenase domain from a modular chitinase from Jonesia denitrificans==
+<StructureSection load='5aa7' size='340' side='right'caption='[[5aa7]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5aa7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Jonesia_denitrificans Jonesia denitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AA7 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aa7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aa7 OCA], [https://pdbe.org/5aa7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aa7 RCSB], [https://www.ebi.ac.uk/pdbsum/5aa7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aa7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/C7R4I0_JONDD C7R4I0_JONDD]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Lytic polysaccharide monooxygenases (LPMOs) boost enzymatic depolymerization of recalcitrant polysaccharides, such as chitin and cellulose. We have studied a chitin-active LPMO domain (JdLPMO10A) that is considerably smaller (15.5 kDa) than all structurally characterized LPMOs so far and that is part of a modular protein containing a GH18 chitinase. The 1.55 A resolution structure revealed deletions of interacting loops that protrude from the core beta-sandwich scaffold in larger LPMO10s. Despite these deletions, the enzyme is active on alpha- and beta-chitin, and the chitin-binding surface previously described for larger LPMOs is fully conserved. JdLPMO10A may represent a minimal scaffold needed to catalyse the powerful LPMO reaction.
-Authors: Mekasha, S., Forsberg, Z., Dalhus, B., Choudhary, S., Schmidt-Dannert, C., Vaaje-Kolstad, G., Eijsink, V.
+Structural and functional characterization of a small chitin-active lytic polysaccharide monooxygenase domain of a multi-modular chitinase from Jonesia denitrificans.,Mekasha S, Forsberg Z, Dalhus B, Bacik JP, Choudhary S, Schmidt-Dannert C, Vaaje-Kolstad G, Eijsink VG FEBS Lett. 2016 Jan;590(1):34-42. doi: 10.1002/1873-3468.12025. Epub 2015 Dec 28. PMID:26763108<ref>PMID:26763108</ref>
-Description: Structural and functional characterization of a chitin-active 15.5 kDa lytic polysaccharide monooxygenase domain from a modular chitinase from Jonesia denitrificans
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Forsberg, Z]]
+<div class="pdbe-citations 5aa7" style="background-color:#fffaf0;"></div>
-[[Category: Eijsink, V]]
-[[Category: Mekasha, S]]
+==See Also==
-[[Category: Schmidt-Dannert, C]]
+*[[Chitinase 3D structures|Chitinase 3D structures]]
-[[Category: Vaaje-Kolstad, G]]
+== References ==
-[[Category: Choudhary, S]]
+<references/>
-[[Category: Dalhus, B]]
+__TOC__
+</StructureSection>
+[[Category: Jonesia denitrificans]]
+[[Category: Large Structures]]
+[[Category: Choudhary S]]
+[[Category: Dalhus B]]
+[[Category: Eijsink V]]
+[[Category: Forsberg Z]]
+[[Category: Mekasha S]]
+[[Category: Schmidt-Dannert C]]
+[[Category: Vaaje-Kolstad G]]