5d9h: Difference between revisions

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'''Unreleased structure'''


The entry 5d9h is ON HOLD
==Crystal structure of SPAK (STK39) dimer in the basal activity state==
<StructureSection load='5d9h' size='340' side='right'caption='[[5d9h]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5d9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D9H FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9h OCA], [https://pdbe.org/5d9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d9h RCSB], [https://www.ebi.ac.uk/pdbsum/5d9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9h ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STK39_MOUSE STK39_MOUSE] May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (PubMed:21317537, PubMed:23542070).<ref>PMID:21317537</ref> <ref>PMID:23542070</ref>


Authors: Taylor, C.A., Juang, Y.C., Goldsmith, E.J., Cobb, M.H.
==See Also==
 
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
Description: Crystal structure of SPAK (STK39) dimer in the basal activity state
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Juang, Y.C]]
__TOC__
[[Category: Taylor, C.A]]
</StructureSection>
[[Category: Cobb, M.H]]
[[Category: Large Structures]]
[[Category: Goldsmith, E.J]]
[[Category: Mus musculus]]
[[Category: Cobb MH]]
[[Category: Goldsmith EJ]]
[[Category: Juang YC]]
[[Category: Taylor CA]]

Latest revision as of 15:23, 6 March 2024

Crystal structure of SPAK (STK39) dimer in the basal activity stateCrystal structure of SPAK (STK39) dimer in the basal activity state

Structural highlights

5d9h is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.1Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

STK39_MOUSE May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (PubMed:21317537, PubMed:23542070).[1] [2]

See Also

References

  1. ↑ Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K, Thomas PJ, Muallem S. IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011 Mar;121(3):956-65. doi: 10.1172/JCI43475. Epub 2011 Feb 7. PMID:21317537 doi:http://dx.doi.org/10.1172/JCI43475
  2. ↑ Park S, Shcheynikov N, Hong JH, Zheng C, Suh SH, Kawaai K, Ando H, Mizutani A, Abe T, Kiyonari H, Seki G, Yule D, Mikoshiba K, Muallem S. Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013 Jul;145(1):232-41. doi: 10.1053/j.gastro.2013.03.047. Epub, 2013 Mar 28. PMID:23542070 doi:http://dx.doi.org/10.1053/j.gastro.2013.03.047

5d9h, resolution 3.10Å

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