4udf: Difference between revisions

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 ==STRUCTURAL BASIS OF HUMAN PARECHOVIRUS NEUTRALIZATION BY HUMAN MONOCLONAL ANTIBODIES==
-<StructureSection load='4udf' size='340' side='right' caption='[[4udf]], [[Resolution|resolution]] 20.00&Aring;' scene=''>
+<SX load='4udf' size='340' side='right' viewer='molstar' caption='[[4udf]], [[Resolution|resolution]] 20.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4udf]] is a 240 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_parechovirus_1_(strain_harris) Human parechovirus 1 (strain harris)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UDF FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4udf]] is a 240 chain structure with sequence from [https://en.wikipedia.org/wiki/Echovirus_22_(strain_Harris) Echovirus 22 (strain Harris)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UDF FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4udf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4udf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4udf RCSB], [http://www.ebi.ac.uk/pdbsum/4udf PDBsum]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 20&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4udf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4udf OCA], [https://pdbe.org/4udf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4udf RCSB], [https://www.ebi.ac.uk/pdbsum/4udf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4udf ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/POLG_HPE1H POLG_HPE1H]] Capsid proteins VP0, VP2, VP3 form a closed capsid enclosing the viral positive strand RNA genome. Capsid proteins interact with host alpha-V/beta-3 integrin heterodimer to provide virion attachment target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:11160695</ref>   Protein 2A: Is not a protease.  Protein 2B: Affects membrane integrity and cause an increase in membrane permeability.  Protein 2C: Associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).  Protein 3A, via its hydrophobic domain, serves as membrane anchor.  Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease (By similarity).  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.[PROSITE-ProRule:PRU00539]
+[https://www.uniprot.org/uniprot/POLG_HPE1H POLG_HPE1H] Capsid proteins VP0, VP2, VP3 form a closed capsid enclosing the viral positive strand RNA genome. Capsid proteins interact with host alpha-V/beta-3 integrin heterodimer to provide virion attachment target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:11160695</ref>   Protein 2A: Is not a protease.  Protein 2B: Affects membrane integrity and cause an increase in membrane permeability.  Protein 2C: Associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).  Protein 3A, via its hydrophobic domain, serves as membrane anchor.  Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease (By similarity).  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.[PROSITE-ProRule:PRU00539]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4udf" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
 == References ==
 <references/>
 __TOC__
-</StructureSection>
+</SX>
 [[Category: Homo sapiens]]
-[[Category: Bakker, A Q]]
+[[Category: Large Structures]]
-[[Category: Beaumont, T]]
+[[Category: Bakker AQ]]
-[[Category: Butcher, S J]]
+[[Category: Beaumont T]]
-[[Category: Claassen, Y]]
+[[Category: Butcher SJ]]
-[[Category: Koen, G]]
+[[Category: Claassen Y]]
-[[Category: Ora, A]]
+[[Category: Koen G]]
-[[Category: Shakeel, S]]
+[[Category: Ora A]]
-[[Category: Westerhuis, B M]]
+[[Category: Shakeel S]]
-[[Category: Wolthers, K C]]
+[[Category: Westerhuis BM]]
-[[Category: Hpev1-am28 fab]]
+[[Category: Wolthers KC]]
-[[Category: Human monoclonal antibody]]
-[[Category: Human parechovirus 1]]
-[[Category: Virus]]