Signalosome: Difference between revisions

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<StructureSection load='4d10' size='340' side='right' caption='Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and ), 7A (gold and ), 8 (red and neon green) (PDB code [[4d10]])' scene=''>
<StructureSection load='4d10' size='340' side='right' caption='Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and orchid), 7A (gold and turquoise), 8 (red and neon green) (PDB code [[4d10]])' scene=''>
'''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase.  COP9 functions in the ubiquitin-proteasome pathway.  COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome.
'''COP9 (COnstitutive Photomorphogenesis 9) signalosome''' catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase.  COP9 functions in the ubiquitin-proteasome pathway.  COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome<ref>PMID:16045761</ref>.
 
== Function ==
 
== Disease ==
 
== Relevance ==
 
== Structural highlights ==
 


</StructureSection>
</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[4d0p]] – hCOP9 subunit 4 – human <br />
[[4lct]] – hCOP9 subunit 1 – human <br />
[[6a73]] – hCOP9 subunit 2 + IP6<br />
[[4d0p]] – hCOP9 subunit 4 <br />
[[1ufm]] – hCOP9 subunit 4 PCI domain - NMR<br />
[[1ufm]] – hCOP9 subunit 4 PCI domain - NMR<br />
[[4f7o]] – hCOP9 subunit 5  <br />
[[4f7o]] – hCOP9 subunit 5  <br />
[[5jog]], [[5joh]], [[5m5q]] – hCOP9 subunit 5 + inhibitor <br />
[[4qft]] – hCOP9 subunit 6 <br />
[[4qft]] – hCOP9 subunit 6 <br />
[[4e0q]], [[4r14]] – hCOP9 subunit 6 MPN domain <br />
[[4e0q]], [[4r14]] – hCOP9 subunit 6 MPN domain <br />
[[4d10]], [[4d18]] – hCOP9 subunits 1,2,3,4,5,6,7A,8  <br />
[[4d10]], [[4d18]], [[4wsn]] – hCOP9 subunits 1,2,3,4,5,6,7A,8 <br />
[[6r7n]], [[6r7i]], [[6r7h]] – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM <br />
[[6r7f]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM <br />
[[8h3f]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 – Cryo EM <br />
[[8h38]], [[8h3a]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 + Nedd8 – Cryo EM <br />
[[6r6h]] – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM <br />
[[3chm]] – hCOP9 subunit 7 – ''Arabidopsis thaliana''  <br />
[[7enf]], [[7ewm]] – COP9 subunit 12 + Thp3 + 26S proteasome subunit Sem1 – yeast <br />


== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]

Latest revision as of 14:05, 20 November 2023

COP9 (COnstitutive Photomorphogenesis 9) signalosome catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase. COP9 functions in the ubiquitin-proteasome pathway. COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome[1].


Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and orchid), 7A (gold and turquoise), 8 (red and neon green) (PDB code 4d10)

Drag the structure with the mouse to rotate

3D Structures of COP9 signalosome3D Structures of COP9 signalosome

Updated on 20-November-2023

4lct – hCOP9 subunit 1 – human
6a73 – hCOP9 subunit 2 + IP6
4d0p – hCOP9 subunit 4
1ufm – hCOP9 subunit 4 PCI domain - NMR
4f7o – hCOP9 subunit 5
5jog, 5joh, 5m5q – hCOP9 subunit 5 + inhibitor
4qft – hCOP9 subunit 6
4e0q, 4r14 – hCOP9 subunit 6 MPN domain
4d10, 4d18, 4wsn – hCOP9 subunits 1,2,3,4,5,6,7A,8
6r7n, 6r7i, 6r7h – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM
6r7f – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM
8h3f – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 – Cryo EM
8h38, 8h3a – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 + Nedd8 – Cryo EM
6r6h – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM
3chm – hCOP9 subunit 7 – Arabidopsis thaliana
7enf, 7ewm – COP9 subunit 12 + Thp3 + 26S proteasome subunit Sem1 – yeast

ReferencesReferences

  1. ↑ Huang X, Hetfeld BK, Seifert U, Kahne T, Kloetzel PM, Naumann M, Bech-Otschir D, Dubiel W. Consequences of COP9 signalosome and 26S proteasome interaction. FEBS J. 2005 Aug;272(15):3909-17. PMID:16045761 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04807.x

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Michal Harel
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