Thiol:disulfide interchange protein: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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+<StructureSection load='' size='340' side='right' caption='E. coli DsbC complex with MES (PDB code [[1eej]])' scene='70/705687/Cv/1'>
-<StructureSection load='1eej' size='340' side='right' caption='E. coli DsbC (PDB code [[1eej]])' scene=''>
+__TOC__
-'''Thiol:disulfide interchange protein''' (DsbC) is a prokaryotic disulfide bond isomerase.  DsbC acts as a proofreader and breaks the incorrectly formed disulfide bonds.  It contains the CXXC motif.  DsbC is activated by the N terminal domain of DsbD.
 == Function ==
+'''Thiol:disulfide interchange protein''' is a prokaryotic disulfide bond isomerase.  <br />
-== Disease ==
+*'''DsbA''' see [[Protein disulfide oxidoreductase]]<br />
+*'''DsbC''' acts as a proofreader and breaks the incorrectly formed disulfide bonds.  DsbC is activated by the N terminal domain of DsbD<ref>PMID:9352906</ref>.<br />
-== Relevance ==
+*'''DsbD''' transfers electrons from the cytoplasmic thioredoxin to the periplasm thus maintaining the active site of DsbC, DsbE and DsbG in a reduced state<ref>PMID:10712691</ref>.<br />
+*'''DsbE''' catalyzes the reductive step in the assembly of periplasmic c-type cytochrome<ref>PMID:14597624</ref>.  <br />
+*'''DsbG''' provides reducing equivalents to rescue oxidatively-damaged secreted proteins<ref>PMID:9654144</ref>.
 == Structural highlights ==
+DsbC active site contains a <scene name='70/705687/Cv/2'>CXXC motif</scene> which modulates the disulfide isomerization and protein folding in the bacterial periplasmic space<ref>PMID:11208797</ref><ref>PMID:11208797</ref>.
+== 3D Structures of thiol:disulfide interchange protein ==
+[[Thiol:disulfide interchange protein 3D structures]]
 </StructureSection>
-== 3D Structures of thiol:disulfide interchange protein ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1eej]], [[1tjd]] – EcDsbC – Escherichal coli <BR />
-[[1g0t]], [[1jzo]] – EcDsbC (mutant) <BR />
-[[2iyj]] – EcDsbC N terminal<BR />
-[[1jzd]] – EcDsbC (mutant) + DsbD N terminal<BR />
-[[1t3b]] – DsbC – Haemophilus influenzae <BR />
-[[4fyb]], [[4fyc]] – DsbC – Helicobacter pylori <BR />
-[[4i5q]] – StDsbC – Salmonella typhimurium<BR />
-[[4ilf]] – StDsbC (mutant) <BR />
 == References ==
 <references/>
+[[Category:Topic Page]]