5bqh: Difference between revisions

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'''Unreleased structure'''


The entry 5bqh is ON HOLD  until Paper Publication
==Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain==
<StructureSection load='5bqh' size='340' side='right'caption='[[5bqh]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5bqh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BQH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.601&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KA:(2-HYDROXYETHOXY)ACETALDEHYDE'>1KA</scene>, <scene name='pdbligand=4UK:N-[4-(4-CHLOROPHENYL)-1H-IMIDAZOL-2-YL]-2-(DIFLUOROMETHYL)-5-{[(2-METHYLPROPANOYL)AMINO]METHYL}BENZAMIDE'>4UK</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqh OCA], [https://pdbe.org/5bqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bqh RCSB], [https://www.ebi.ac.uk/pdbsum/5bqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>


Authors: Fisher, M.J., Schiffler, M.A., Kuklish, S.L., Antonysamy, S., Luz, J.G.
==See Also==
 
*[[Prostaglandin E synthase|Prostaglandin E synthase]]
Description: Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Luz, J.G]]
__TOC__
[[Category: Fisher, M.J]]
</StructureSection>
[[Category: Kuklish, S.L]]
[[Category: Homo sapiens]]
[[Category: Antonysamy, S]]
[[Category: Large Structures]]
[[Category: Schiffler, M.A]]
[[Category: Antonysamy S]]
[[Category: Fisher MJ]]
[[Category: Kuklish SL]]
[[Category: Luz JG]]
[[Category: Schiffler MA]]

Latest revision as of 15:17, 6 March 2024

Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of PainDiscovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain

Structural highlights

5bqh is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.601Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PTGES_HUMAN Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).[1]

See Also

References

  1. ↑ Jegerschold C, Pawelzik SC, Purhonen P, Bhakat P, Gheorghe KR, Gyobu N, Mitsuoka K, Morgenstern R, Jakobsson PJ, Hebert H. Structural basis for induced formation of the inflammatory mediator prostaglandin E2. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11110-5. Epub 2008 Aug 5. PMID:18682561 doi:0802894105

5bqh, resolution 1.60Å

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