5a18: Difference between revisions
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==The structure of the SOLE element of oskar mRNA== | ==The structure of the SOLE element of oskar mRNA== | ||
<StructureSection load='5a18' size='340' side='right' caption='[[5a18 | <StructureSection load='5a18' size='340' side='right'caption='[[5a18]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5a18]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A18 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5a18]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A18 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a18 OCA], [https://pdbe.org/5a18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a18 RCSB], [https://www.ebi.ac.uk/pdbsum/5a18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a18 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
mRNA localization by active transport is a regulated process that requires association of mRNPs with protein motors for transport along either the microtubule or the actin cytoskeleton. oskar mRNA localization at the posterior pole of the Drosophila oocyte requires a specific mRNA sequence, termed the SOLE, which comprises nucleotides of both exon 1 and exon 2 and is assembled upon splicing. The SOLE folds into a stem-loop structure. Both SOLE RNA and the exon junction complex (EJC) are required for oskar mRNA transport along the microtubules by kinesin. The SOLE RNA likely constitutes a recognition element for a yet unknown protein, which either belongs to the EJC or functions as a bridge between the EJC and the mRNA. Here, we determine the solution structure of the SOLE RNA by Nuclear Magnetic Resonance spectroscopy. We show that the SOLE forms a continuous helical structure, including a few noncanonical base pairs, capped by a pentanucleotide loop. The helix displays a widened major groove, which could accommodate a protein partner. In addition, the apical helical segment undergoes complex dynamics, with potential functional significance. | |||
The structure of the SOLE element of oskar mRNA.,Simon B, Masiewicz P, Ephrussi A, Carlomagno T RNA. 2015 Jun 18. PMID:26089324<ref>PMID:26089324</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5a18" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Drosophila melanogaster]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Carlomagno T]] | ||
[[Category: | [[Category: Ephrussi A]] | ||
[[Category: | [[Category: Masiewicz P]] | ||
[[Category: | [[Category: Simon B]] | ||