2ypr: Difference between revisions

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==Crystal structure of the DNA binding ETS domain of human protein FEV==
==Crystal structure of the DNA binding ETS domain of human protein FEV==
<StructureSection load='2ypr' size='340' side='right' caption='[[2ypr]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
<StructureSection load='2ypr' size='340' side='right'caption='[[2ypr]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ypr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YPR FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ypr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ypr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ypr RCSB], [http://www.ebi.ac.uk/pdbsum/2ypr PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ypr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypr OCA], [https://pdbe.org/2ypr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ypr RCSB], [https://www.ebi.ac.uk/pdbsum/2ypr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypr ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry.  A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.  
[https://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry.  A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref>
[https://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2ypr" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Allerston, C K]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Allerston CK]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Cooper, C]]
[[Category: Bountra C]]
[[Category: Delft, F von]]
[[Category: Cooper C]]
[[Category: Edwards, A]]
[[Category: Edwards A]]
[[Category: Gileadi, O]]
[[Category: Gileadi O]]
[[Category: Krojer, T]]
[[Category: Krojer T]]
[[Category: Vollmar, M]]
[[Category: Vollmar M]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Transcription]]
[[Category: Von Delft F]]

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