2ypr: Difference between revisions
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==Crystal structure of the DNA binding ETS domain of human protein FEV== | ==Crystal structure of the DNA binding ETS domain of human protein FEV== | ||
<StructureSection load='2ypr' size='340' side='right' caption='[[2ypr]], [[Resolution|resolution]] 2.64Å' scene=''> | <StructureSection load='2ypr' size='340' side='right'caption='[[2ypr]], [[Resolution|resolution]] 2.64Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ypr]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ypr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPR FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ypr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypr OCA], [https://pdbe.org/2ypr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ypr RCSB], [https://www.ebi.ac.uk/pdbsum/2ypr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypr ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2ypr" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Allerston CK]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Cooper C]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Gileadi | [[Category: Gileadi O]] | ||
[[Category: Krojer | [[Category: Krojer T]] | ||
[[Category: Vollmar | [[Category: Vollmar M]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: | [[Category: Von Delft F]] |