4z76: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 4z76 is ON HOLD
+==Weak TCR binding to an unstable insulin epitope drives type 1 diabetes==
+<StructureSection load='4z76' size='340' side='right'caption='[[4z76]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4z76]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z76 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z76 OCA], [https://pdbe.org/4z76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z76 RCSB], [https://www.ebi.ac.uk/pdbsum/4z76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z76 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HA1D_MOUSE HA1D_MOUSE] Involved in the presentation of foreign antigens to the immune system.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The NOD mouse model of type 1 diabetes (T1D) continues to be an important tool for delineating the role of T-cell-mediated destruction of pancreatic beta-cells. However, little is known about the molecular mechanisms that enable this disease pathway. We show that insulin reactivity by a CD8+ T-cell clone known to induce T1D is characterised by weak T cell antigen receptor (TCR) binding to a relatively unstable peptide-major histocompatibility complex (pMHC). The structure of the native 9-mer and 10-mer insulin epitopes demonstrated that peptide residues 7 and 8 form a prominent solvent exposed bulge that could potentially be the main focus of TCR binding. The C-terminus of the peptide governed pMHC stability. Unexpectedly, we further demonstrate a novel mode of flexible peptide presentation in which the MHC peptide-binding groove is able to 'open the back door' to accommodate extra C-terminal peptide residues.
-Authors: Rizkallah, P.J., Cole, D.K.
+Distortion of the MHC class I binding groove to accommodate an insulin-derived 10-mer peptide.,Motozono C, Pearson JA, De Leenheer E, Rizkallah PJ, Beck K, Trimby A, Sewell AK, Wong FS, Cole DK J Biol Chem. 2015 Jun 17. pii: jbc.M114.622522. PMID:26085090<ref>PMID:26085090</ref>
-Description: Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Cole, D.K]]
+<div class="pdbe-citations 4z76" style="background-color:#fffaf0;"></div>
-[[Category: Rizkallah, P.J]]
+==See Also==
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Cole DK]]
+[[Category: Rizkallah PJ]]