4wu9: Difference between revisions
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==Structure of cisPtNAP-NCP145== | |||
<StructureSection load='4wu9' size='340' side='right'caption='[[4wu9]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4wu9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WU9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CX8:[2-{3-[(2-{[2-(AMINO-KAPPAN)ETHYL]AMINO-KAPPAN}ETHYL)AMINO-KAPPAN]PROPYL}-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONATO(3-)]PLATINUM'>CX8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wu9 OCA], [https://pdbe.org/4wu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wu9 RCSB], [https://www.ebi.ac.uk/pdbsum/4wu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wu9 ProSAT]</span></td></tr> | ||
[[Category: Ang | </table> | ||
[[Category: | == Function == | ||
[[Category: Davey | [https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Ang WH]] | |||
[[Category: Chin CF]] | |||
[[Category: Chua EYD]] | |||
[[Category: Davey CA]] | |||
[[Category: Davey GE]] | |||
[[Category: Droge P]] | |||
Latest revision as of 12:02, 20 March 2024
Structure of cisPtNAP-NCP145Structure of cisPtNAP-NCP145
Structural highlights
FunctionH4_XENLA Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
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