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| <StructureSection load='3icq' size='340' side='right' caption='Structure of yeast exportin-5 (dark green and dark red) complex with GTPaseRan (pale green and pink), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene=''> | | <StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/9'> |
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| == Function ==
| | '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. <br /> |
| | *'''XPO-1''' mediates nuclear transport of cellular proteins bearing a Leu-rich nuclear export signal and of RNA<ref>PMID:36727672</ref>.<br /> |
| | *'''XPO-4''' mediates nuclear transport of eukaryotic translation initiation factor 5A<ref>PMID:10944119</ref>.<br /> |
| | *'''XPO-5''' mediates nuclear transport of pre-miroRNAs and short hairpin RNAs<ref>PMID:14681208</ref>.<br /> |
| | *'''XPO-t''' or '''karyopherin''' is a nuclear transport receptor involved in the export of tRNA to the cytoplasm<ref>PMID:22944664</ref>.<br /> |
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| '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus.
| | ==Structural highlights == |
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| == Disease == | | <scene name='59/592125/Cv/10'>Yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene>. |
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| == Relevance == | | <scene name='59/592125/Cv/11'>GTP binding site</scene>. |
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| == Structural highlights == | | <scene name='59/592125/Cv/12'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref> |
| </StructureSection> | |
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| ==3D structures of exportin== | | ==3D structures of exportin== |
| | [[Exportin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *XPO-1
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| **[[4bsm]], [[4bsn]] – hXPO – human<br />
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| **[[1w9c]] – hXPO C terminal 6 heat repeats <br />
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| **[[3vyc]] – yXPO (mutant) - yeast<br />
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| **[[4fgv]] – XPO – ''Chaetomium thermophilum''<br />
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| *XPO-1 complexes
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| **[[3gb8]] – hXPO + RNA U transporter 1 <br />
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| **[[3gjx]] – hXPO + RNA U transporter 1 + GTPaseRan<br />
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| **[[3m1i]], [[4gpt]], [[4gmx]], [[4hat]], [[4hb2]] – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein <br />
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| **[[3wyf]] – yXPO + GTP-binding nuclear protein + Ran-specific GTPase-activating protein <br />
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| **[[3wyg]] – yXPO + GTP-binding nuclear protein + PKI-alpha<br />
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| **[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein + antibiotic<br />
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| **[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + GTPaseRan - mouse<br />
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| **[[3nc1]] – mXPO + GTPaseRan<br />
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| **[[2l1l]] – hXPO residues 504-630 + cAMP-dependent protein kinase inhibitor α - NMR<br />
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| *XPO-t
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| **[[3ibv]] – fyXPO – fission yeast<br />
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| **[[3icq]] – fyXPO + GTP-binding nuclear protein + RNA <br />
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| *XPO-5
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| **[[3a6p]] – hXPO + peptide + pre-microRNA <br />
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| }}
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| == References == | | == References == |