2n14: Difference between revisions

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New page: '''Unreleased structure''' The entry 2n14 is ON HOLD Authors: Grace, C., Kriwacki, R. Description: MDMX-295 Category: Unreleased Structures Category: Kriwacki, R [[Category: Gr...
 
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'''Unreleased structure'''


The entry 2n14 is ON HOLD
==Mdmx-295==
<StructureSection load='2n14' size='340' side='right'caption='[[2n14]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2n14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N14 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49H:4-({(4S,5R)-4-(3-CHLOROPHENYL)-5-(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>49H</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n14 OCA], [https://pdbe.org/2n14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n14 RCSB], [https://www.ebi.ac.uk/pdbsum/2n14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n14 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>


Authors: Grace, C., Kriwacki, R.
==See Also==
 
*[[MDM4|MDM4]]
Description: MDMX-295
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Kriwacki, R]]
__TOC__
[[Category: Grace, C]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Grace CR]]
[[Category: Kriwacki RW]]

Latest revision as of 10:03, 1 May 2024

Mdmx-295Mdmx-295

Structural highlights

2n14 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MDM4_HUMAN Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.[1] [2]

See Also

References

  1. ↑ Chen L, Gilkes DM, Pan Y, Lane WS, Chen J. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 2005 Oct 5;24(19):3411-22. Epub 2005 Sep 15. PMID:16163388 doi:10.1038/sj.emboj.7600812
  2. ↑ Jin Y, Dai MS, Lu SZ, Xu Y, Luo Z, Zhao Y, Lu H. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006 Mar 22;25(6):1207-18. Epub 2006 Mar 2. PMID:16511572 doi:10.1038/sj.emboj.7601010
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