4yhc: Difference between revisions
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==Crystal structure of the WD40 domain of SCAP from fission yeast== | |||
<StructureSection load='4yhc' size='340' side='right'caption='[[4yhc]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4yhc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YHC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yhc OCA], [https://pdbe.org/4yhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yhc RCSB], [https://www.ebi.ac.uk/pdbsum/4yhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yhc ProSAT]</span></td></tr> | ||
[[Category: Gong | </table> | ||
[[Category: | == Function == | ||
[[Category: Yan | [https://www.uniprot.org/uniprot/SCAP_SCHPO SCAP_SCHPO] Escort protein required for sre1 processing at low sterol as well as oxygen levels. May regulate export of the scp1/sre1 complex from the ER at low sterol or oxygen levels. 4-methyl sterols bound to scp1 may mask an ER-export signal in scp1 leading to retention of the complex in the ER. Release of 4-methyl sterols may trigger a conformational change in the SSC domain of scp1 unmasking the ER export signal leading to recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of sre1 in the Golgi, release of the transcription factor fragment of sre1 from the membrane, its import into the nucleus and up-regulation of genes required for ergosterol biosynthesis as well as anaerobic growth.[UniProtKB:P97260]<ref>PMID:15797383</ref> <ref>PMID:17595166</ref> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Schizosaccharomyces pombe 972h-]] | |||
[[Category: Gong X]] | |||
[[Category: Li JX]] | |||
[[Category: Wu JP]] | |||
[[Category: Yan CY]] | |||
[[Category: Yan N]] | |||
Latest revision as of 12:03, 20 March 2024
Crystal structure of the WD40 domain of SCAP from fission yeastCrystal structure of the WD40 domain of SCAP from fission yeast
Structural highlights
FunctionSCAP_SCHPO Escort protein required for sre1 processing at low sterol as well as oxygen levels. May regulate export of the scp1/sre1 complex from the ER at low sterol or oxygen levels. 4-methyl sterols bound to scp1 may mask an ER-export signal in scp1 leading to retention of the complex in the ER. Release of 4-methyl sterols may trigger a conformational change in the SSC domain of scp1 unmasking the ER export signal leading to recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of sre1 in the Golgi, release of the transcription factor fragment of sre1 from the membrane, its import into the nucleus and up-regulation of genes required for ergosterol biosynthesis as well as anaerobic growth.[UniProtKB:P97260][1] [2] References
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