2n06: Difference between revisions

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-'''Unreleased structure'''
-The entry 2n06 is ON HOLD
+==Mdmx-298==
+<StructureSection load='2n06' size='340' side='right'caption='[[2n06]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2n06]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N06 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=44Z:4-[[(4S,5R)-5-(4-CHLOROPHENYL)-4-(3-METHOXYPHENYL)-2-(4-METHOXY-2-PROPAN-2-YLOXY-PHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]CARBONYL]PIPERAZIN-2-ONE'>44Z</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n06 OCA], [https://pdbe.org/2n06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n06 RCSB], [https://www.ebi.ac.uk/pdbsum/2n06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n06 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
-Authors: Grace, C.R., Kriwacki, R.W.
+==See Also==
+*[[MDM4|MDM4]]
-Description: Mdmx-298
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Kriwacki, R.W]]
+__TOC__
-[[Category: Grace, C.R]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Grace CR]]
+[[Category: Kriwacki RW]]