2mzw: Difference between revisions
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==Staphylococcus aureus FusB:EF-GC3 complex== | |||
<StructureSection load='2mzw' size='340' side='right'caption='[[2mzw]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mzw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mzw OCA], [https://pdbe.org/2mzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mzw RCSB], [https://www.ebi.ac.uk/pdbsum/2mzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mzw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/EFG_STAA8 EFG_STAA8] Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.[HAMAP-Rule:MF_00054] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism mediated through a protein-protein interaction, revealing the architecture of the complex formed between the FusB fusidic acid resistance protein and the drug target (EF-G) it acts to protect. Binding of FusB to EF-G induces conformational and dynamic changes in the latter, shedding light on the molecular mechanism of fusidic acid resistance. | |||
A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance.,Tomlinson JH, Thompson GS, Kalverda AP, Zhuravleva A, O'Neill AJ Sci Rep. 2016 Jan 19;6:19524. doi: 10.1038/srep19524. PMID:26781961<ref>PMID:26781961</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 2mzw" style="background-color:#fffaf0;"></div> | ||
[[Category: | |||
[[Category: | ==See Also== | ||
[[Category: Tomlinson | *[[Elongation factor 3D structures|Elongation factor 3D structures]] | ||
[[Category: Zhuravleva | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus]] | |||
[[Category: Kalverda AP]] | |||
[[Category: O'Neill A]] | |||
[[Category: Thompson GS]] | |||
[[Category: Tomlinson JH]] | |||
[[Category: Zhuravleva A]] | |||
Latest revision as of 09:12, 15 May 2024
Staphylococcus aureus FusB:EF-GC3 complexStaphylococcus aureus FusB:EF-GC3 complex
Structural highlights
FunctionEFG_STAA8 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.[HAMAP-Rule:MF_00054] Publication Abstract from PubMedAntibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism mediated through a protein-protein interaction, revealing the architecture of the complex formed between the FusB fusidic acid resistance protein and the drug target (EF-G) it acts to protect. Binding of FusB to EF-G induces conformational and dynamic changes in the latter, shedding light on the molecular mechanism of fusidic acid resistance. A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance.,Tomlinson JH, Thompson GS, Kalverda AP, Zhuravleva A, O'Neill AJ Sci Rep. 2016 Jan 19;6:19524. doi: 10.1038/srep19524. PMID:26781961[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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