4y2p: Difference between revisions

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-'''Unreleased structure'''
-The entry 4y2p is ON HOLD
+==Structure of soluble epoxide hydrolase in complex with N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine==
+<StructureSection load='4y2p' size='340' side='right'caption='[[4y2p]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4y2p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y2P FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3C5:N-METHYL-1-[3-(PYRIDIN-3-YL)PHENYL]METHANAMINE'>3C5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2p OCA], [https://pdbe.org/4y2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y2p RCSB], [https://www.ebi.ac.uk/pdbsum/4y2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y2p ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
-Authors: Amano, Y., Yamaguchi, T.
+==See Also==
+*[[Epoxide hydrolase 3D structures|Epoxide hydrolase 3D structures]]
-Description: Structure of soluble epoxide hydrolase in complex with N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Amano, Y]]
+__TOC__
-[[Category: Yamaguchi, T]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Amano Y]]
+[[Category: Yamaguchi T]]