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==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==
==CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION==
<StructureSection load='1ckw' size='340' side='right' caption='[[1ckw]], [[NMR_Ensembles_of_Models | 13 NMR models]]' scene=''>
<StructureSection load='1ckw' size='340' side='right'caption='[[1ckw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ckw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CKW FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ckw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CKW FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ckw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ckw RCSB], [http://www.ebi.ac.uk/pdbsum/1ckw PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ckw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ckw OCA], [https://pdbe.org/1ckw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ckw RCSB], [https://www.ebi.ac.uk/pdbsum/1ckw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ckw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CFTR_SHEEP CFTR_SHEEP]] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).  
[https://www.uniprot.org/uniprot/CFTR_SHEEP CFTR_SHEEP] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1ckw" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[ABC transporter|ABC transporter]]
*[[ABC transporter 3D structures|ABC transporter 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ko, Y H]]
[[Category: Large Structures]]
[[Category: Massiah, M A]]
[[Category: Ovis aries]]
[[Category: Mildvan, A S]]
[[Category: Ko YH]]
[[Category: Pedersen, P L]]
[[Category: Massiah MA]]
[[Category: Cystic fibrosis]]
[[Category: Mildvan AS]]
[[Category: Metal transport]]
[[Category: Pedersen PL]]
[[Category: P25_tfe]]
[[Category: Peptide]]

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