4xuj: Difference between revisions
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New page: '''Unreleased structure''' The entry 4xuj is ON HOLD Authors: Adhireksan, Z., Davey, C.A. Description: X-ray structure of NCP containing RuII-arene complex of thiomorpholine substitute... |
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==Nucleosome core particle containing adducts from treatment with a thiomorpholine-substituted [(eta-6-p-cymene)Ru(3-hydroxy-2-pyridone)Cl] compound== | |||
<StructureSection load='4xuj' size='340' side='right'caption='[[4xuj]], [[Resolution|resolution]] 3.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xuj]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XUJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.18Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4A6:[(1,2,3,4,5,6-ETA)-1-METHYL-4-(PROPAN-2-YL)BENZENE]RUTHENIUM'>4A6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuj OCA], [https://pdbe.org/4xuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xuj RCSB], [https://www.ebi.ac.uk/pdbsum/4xuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xuj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
==See Also== | |||
*[[Histone 3D structures|Histone 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Adhireksan | [[Category: Large Structures]] | ||
[[Category: Davey | [[Category: Synthetic construct]] | ||
[[Category: Xenopus laevis]] | |||
[[Category: Adhireksan Z]] | |||
[[Category: Davey CA]] | |||
Latest revision as of 18:31, 8 November 2023
Nucleosome core particle containing adducts from treatment with a thiomorpholine-substituted [(eta-6-p-cymene)Ru(3-hydroxy-2-pyridone)Cl] compoundNucleosome core particle containing adducts from treatment with a thiomorpholine-substituted [(eta-6-p-cymene)Ru(3-hydroxy-2-pyridone)Cl] compound
Structural highlights
FunctionH32_XENLA Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. See Also |
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