2w8s: Difference between revisions

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-==CRYSTAL STRUCTURE OF A CATALYTICALLY PROMISCUOUS PHOSPHONATE MONOESTER HYDROLASE FROM BURKHOLDERIA CARYOPHYLLI==
-<StructureSection load='2w8s' size='340' side='right' caption='[[2w8s]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+==CRYSTAL STRUCTURE OF A catalytically promiscuous PHOSPHONATE MONOESTER HYDROLASE FROM Burkholderia caryophylli==
+<StructureSection load='2w8s' size='340' side='right'caption='[[2w8s]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2w8s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_caryophylli Burkholderia caryophylli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W8S FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2w8s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trinickia_caryophylli Trinickia caryophylli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W8S FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FGL:2-AMINOPROPANEDIOIC+ACID'>FGL</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FGL:2-AMINOPROPANEDIOIC+ACID'>FGL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w8s RCSB], [http://www.ebi.ac.uk/pdbsum/2w8s PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w8s OCA], [https://pdbe.org/2w8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w8s RCSB], [https://www.ebi.ac.uk/pdbsum/2w8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w8s ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/BCPMH_TRICW BCPMH_TRICW] Hydrolytic enzyme with a broad substrate specificity acting on phosphate diesters and phosphonate monoesters (PubMed:8824203, PubMed:20133613). Hydrolyzes phosphate mono- and triesters, sulfate monoesters and sulfonate monoesters (PubMed:20133613). Hydrolyzes glyphosate monoesters. Does not hydrolyze DNA or cGMP (PubMed:8824203). Hydrolyzes glyceryl glyphosate, but this substrate has a much lower affinity than the glyphosate monoesters (PubMed:8824203, PubMed:8771792).<ref>PMID:20133613</ref> <ref>PMID:8771792</ref> <ref>PMID:8824203</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/2w8s_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/2w8s_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w8s ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 25: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2w8s" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Burkholderia caryophylli]]
+[[Category: Large Structures]]
-[[Category: Hollfelder, F]]
+[[Category: Trinickia caryophylli]]
-[[Category: Hyvonen, M]]
+[[Category: Hollfelder F]]
-[[Category: Jonas, S]]
+[[Category: Hyvonen M]]
-[[Category: Loo, B Van]]
+[[Category: Jonas S]]
-[[Category: Alkaline phosphatase superfamily]]
+[[Category: Van Loo B]]
-[[Category: Catalytic promiscuity]]
-[[Category: Formylglycine]]
-[[Category: Hydrolase]]
-[[Category: Phosphodiesterase]]
-[[Category: Phosphonate monoester hydrolase]]