2o39: Difference between revisions

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-[[Image:2o39.gif|left|200px]]
- {{Structure
+==Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)==
-|PDB= 2o39 |SIZE=350|CAPTION= <scene name='initialview01'>2o39</scene>, resolution 2.85&Aring;
+<StructureSection load='2o39' size='340' side='right'caption='[[2o39]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
+<table><tr><td colspan='2'>[[2o39]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_adenovirus_11p Human adenovirus 11p]. The December 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O39 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
-|GENE= PIV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=35262 Human adenovirus type 35p]), CD46, MCP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o39 OCA], [https://pdbe.org/2o39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o39 RCSB], [https://www.ebi.ac.uk/pdbsum/2o39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o39 ProSAT]</span></td></tr>
+</table>
-'''Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)'''
+== Function ==
+[https://www.uniprot.org/uniprot/SPIKE_ADE1P SPIKE_ADE1P] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface.
+== Evolutionary Conservation ==
-==Overview==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o3/2o39_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o39 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.
-==Disease==
+Adenovirus type 11 binding alters the conformation of its receptor CD46.,Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T Nat Struct Mol Biol. 2007 Feb;14(2):164-6. Epub 2007 Jan 14. PMID:17220899<ref>PMID:17220899</ref>
-Known diseases associated with this structure: Hemolytic-uremic syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120920 120920]], Measles, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120920 120920]]
-==About this Structure==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-O39 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_type_35p Human adenovirus type 35p]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O39 OCA].
+</div>
+<div class="pdbe-citations 2o39" style="background-color:#fffaf0;"></div>
-==Reference==
+== References ==
-Adenovirus type 11 binding alters the conformation of its receptor CD46., Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T, Nat Struct Mol Biol. 2007 Feb;14(2):164-6. Epub 2007 Jan 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17220899 17220899]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Adenovirus]]
 [[Category: Homo sapiens]]
-[[Category: Human adenovirus type 35p]]
+[[Category: Human adenovirus 11p]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Arnberg, N.]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Persson, D B.]]
+[[Category: Arnberg N]]
-[[Category: Reiter, D M.]]
+[[Category: Persson DB]]
-[[Category: Stehle, T.]]
+[[Category: Reiter DM]]
-[[Category: CA]]
+[[Category: Stehle T]]
-[[Category: ad11]]
-[[Category: adenovirus]]
-[[Category: ccp]]
-[[Category: cd46]]
-[[Category: complement control protein]]
-[[Category: fiber knob]]
-[[Category: mcp]]
-[[Category: membrane cofactor protein]]
-[[Category: scr]]
-[[Category: short consensus repeat]]
-[[Category: virus receptor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:54:32 2008''