2nqa: Difference between revisions

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-[[Image:2nqa.gif|left|200px]]
- {{Structure
+==Catalytic Domain of Human Calpain 8==
-|PDB= 2nqa |SIZE=350|CAPTION= <scene name='initialview01'>2nqa</scene>, resolution 2.200&Aring;
+<StructureSection load='2nqa' size='340' side='right'caption='[[2nqa]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene>
+<table><tr><td colspan='2'>[[2nqa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptomyces_roseus Streptomyces roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQA FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-|GENE= LOC388743 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AR7:AMINO{[(4S)-4-AMINO-5,5-DIHYDROXYPENTYL]AMINO}METHANIMINIUM'>AR7</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqa OCA], [https://pdbe.org/2nqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nqa RCSB], [https://www.ebi.ac.uk/pdbsum/2nqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqa ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CAN2_HUMAN CAN2_HUMAN] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.[https://www.uniprot.org/uniprot/CAN8_HUMAN CAN8_HUMAN] Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/2nqa_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nqa ConSurf].
+<div style="clear:both"></div>
-'''Catalytic Domain of Human Calpain 8'''
+==See Also==
+*[[Calpain 3D structures|Calpain 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-NQA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQA OCA].
-[[Category: Calpain-1]]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Streptomyces roseus]]
-[[Category: Bochkarev, A.]]
+[[Category: Arrowsmith CH]]
-[[Category: Butler-Cole, C.]]
+[[Category: Bochkarev A]]
-[[Category: Davis, T L.]]
+[[Category: Butler-Cole C]]
-[[Category: Dhe-Paganon, S.]]
+[[Category: Davis TL]]
-[[Category: Edwards, A M.]]
+[[Category: Dhe-Paganon S]]
-[[Category: Jr., P J.Finerty.]]
+[[Category: Edwards AM]]
-[[Category: Paramanathan, R.]]
+[[Category: Finerty Jr PJ]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Paramanathan R]]
-[[Category: Sundstrom, M.]]
+[[Category: Sundstrom M]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: ACE]]
-[[Category: CA]]
-[[Category: calpain; calcium-dependent cytoplasmic cysteine proteinases; papain-like; ef-hand; structural genomics; structural genomics consortium; sgc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:49:41 2008''