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==Crystal structure of YagE, a KDG aldolase protein in complex with 2-Keto-3-deoxy gluconate== | ==Crystal structure of YagE, a KDG aldolase protein in complex with 2-Keto-3-deoxy gluconate== | ||
<StructureSection load='4onv' size='340' side='right' caption='[[4onv]], [[Resolution|resolution]] 2.57Å' scene=''> | <StructureSection load='4onv' size='340' side='right'caption='[[4onv]], [[Resolution|resolution]] 2.57Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4onv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ONV OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4onv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ONV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ONV FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KDG:2-KETO-3-DEOXYGLUCONATE'>KDG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KDG:2-KETO-3-DEOXYGLUCONATE'>KDG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4onv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4onv OCA], [https://pdbe.org/4onv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4onv RCSB], [https://www.ebi.ac.uk/pdbsum/4onv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4onv ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/YAGE_ECOLI YAGE_ECOLI] Catalyzes the formation of 2-keto-3-deoxy-galactonate (KDGal) from pyruvate and glyceraldehyde. Overexpression leads to increased growth (over 2 hours) in the presence of the antibiotics norfloxacin, ampicillin and streptomycin. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli K-12]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Bhaskar V]] | ||
[[Category: | [[Category: Krishnaswamy S]] | ||
[[Category: | [[Category: Manicka S]] | ||
[[Category: | [[Category: Manoj Kumar P]] | ||
Latest revision as of 10:16, 27 November 2024
Crystal structure of YagE, a KDG aldolase protein in complex with 2-Keto-3-deoxy gluconateCrystal structure of YagE, a KDG aldolase protein in complex with 2-Keto-3-deoxy gluconate
Structural highlights
FunctionYAGE_ECOLI Catalyzes the formation of 2-keto-3-deoxy-galactonate (KDGal) from pyruvate and glyceraldehyde. Overexpression leads to increased growth (over 2 hours) in the presence of the antibiotics norfloxacin, ampicillin and streptomycin. |
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