2iq1: Difference between revisions

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-[[Image:2iq1.gif|left|200px]]
- {{Structure
+==Crystal structure of human PPM1K==
-|PDB= 2iq1 |SIZE=350|CAPTION= <scene name='initialview01'>2iq1</scene>, resolution 2.250&Aring;
+<StructureSection load='2iq1' size='340' side='right'caption='[[2iq1]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
+<table><tr><td colspan='2'>[[2iq1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-|GENE= DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [https://pdbe.org/2iq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [https://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iq1 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN] Intermediate maple syrup urine disease.
+== Function ==
+[https://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.<ref>PMID:17374715</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/2iq1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iq1 ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of human PPM1K'''
+==See Also==
+*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-IQ1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Adams, J.]]
+[[Category: Adams J]]
-[[Category: Almo, S C.]]
+[[Category: Almo SC]]
-[[Category: Bain, K T.]]
+[[Category: Bain KT]]
-[[Category: Bonanno, J B.]]
+[[Category: Bonanno JB]]
-[[Category: Burley, S K.]]
+[[Category: Burley SK]]
-[[Category: Freeman, J.]]
+[[Category: Freeman J]]
-[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
+[[Category: Pelletier L]]
-[[Category: Pelletier, L.]]
+[[Category: Russell M]]
-[[Category: Russell, M.]]
+[[Category: Sauder JM]]
-[[Category: Sauder, J M.]]
+[[Category: Wasserman S]]
-[[Category: Wasserman, S.]]
-[[Category: MG]]
-[[Category: new york structural genomix research consortium]]
-[[Category: nysgxrc]]
-[[Category: protein phosphatase 2c kappa]]
-[[Category: protein structure initiative]]
-[[Category: psi-2]]
-[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:32:16 2008''