4g2f: Difference between revisions

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 ==Human EphA3 kinase domain in complex with compound 7==
-<StructureSection load='4g2f' size='340' side='right' caption='[[4g2f]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+<StructureSection load='4g2f' size='340' side='right'caption='[[4g2f]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4g2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2F FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4g2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2F FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C07:1-AMINO-5-(5-HYDROXY-2-METHYLPHENYL)-7,8,9,10-TETRAHYDROPYRIMIDO[4,5-C]ISOQUINOLIN-6(5H)-ONE'>C07</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.699&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPHA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C07:1-AMINO-5-(5-HYDROXY-2-METHYLPHENYL)-7,8,9,10-TETRAHYDROPYRIMIDO[4,5-C]ISOQUINOLIN-6(5H)-ONE'>C07</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2f OCA], [https://pdbe.org/4g2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2f RCSB], [https://www.ebi.ac.uk/pdbsum/4g2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2f ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2f RCSB], [http://www.ebi.ac.uk/pdbsum/4g2f PDBsum]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN] Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500].
+== Function ==
+[https://www.uniprot.org/uniprot/EPHA3_HUMAN EPHA3_HUMAN] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.<ref>PMID:11870224</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 20: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4g2f" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Ephrin receptor|Ephrin receptor]]
+*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Receptor protein-tyrosine kinase]]
+[[Category: Large Structures]]
-[[Category: Caflisch, A]]
+[[Category: Caflisch A]]
-[[Category: Dong, J]]
+[[Category: Dong J]]
-[[Category: Atp binding]]
-[[Category: Membrane]]
-[[Category: Phosphorylation]]
-[[Category: Receptor tyrosine kinase]]
-[[Category: Transferase-transferase inhibitor complex]]