4cl1: Difference between revisions

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==The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors==
==The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors==
<StructureSection load='4cl1' size='340' side='right' caption='[[4cl1]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='4cl1' size='340' side='right'caption='[[4cl1]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cl1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_(isolate_h77) Hepatitis c virus (isolate h77)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CL1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cl1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_(isolate_H77) Hepatitis C virus (isolate H77)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CL1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cl1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cl1 RCSB], [http://www.ebi.ac.uk/pdbsum/4cl1 PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cl1 OCA], [https://pdbe.org/4cl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cl1 RCSB], [https://www.ebi.ac.uk/pdbsum/4cl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cl1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/K4KA16_9HEPC K4KA16_9HEPC]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4cl1" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Angell, R]]
[[Category: Large Structures]]
[[Category: Garnett, J A]]
[[Category: Angell R]]
[[Category: Hedgethorne, K]]
[[Category: Garnett JA]]
[[Category: Lambert, S M]]
[[Category: Hedgethorne K]]
[[Category: Langley, D R]]
[[Category: Lambert SM]]
[[Category: Matthews, S J]]
[[Category: Langley DR]]
[[Category: Meanwell, N A]]
[[Category: Matthews SJ]]
[[Category: Viral protein]]
[[Category: Meanwell NA]]

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