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[[Image:2g3y.gif|left|200px]]


{{Structure
==Crystal structure of the human small GTPase GEM==
|PDB= 2g3y |SIZE=350|CAPTION= <scene name='initialview01'>2g3y</scene>, resolution 2.40&Aring;
<StructureSection load='2g3y' size='340' side='right'caption='[[2g3y]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>
<table><tr><td colspan='2'>[[2g3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G3Y FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE= GEM, KIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g3y OCA], [https://pdbe.org/2g3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g3y RCSB], [https://www.ebi.ac.uk/pdbsum/2g3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g3y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GEM_HUMAN GEM_HUMAN] Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/2g3y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g3y ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the human small GTPase GEM'''
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
__TOC__
==Disease==
</StructureSection>
Known diseases associated with this structure: Long QT syndrome-7 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600681 600681]], Short QT syndrome-3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600681 600681]]
 
==About this Structure==
2G3Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G3Y OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Berridge, G.]]
[[Category: Berridge G]]
[[Category: Bray, J.]]
[[Category: Bray J]]
[[Category: Burgess, N.]]
[[Category: Burgess N]]
[[Category: Delft, F von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Fedorov O]]
[[Category: Fedorov, O.]]
[[Category: Gileadi C]]
[[Category: Gileadi, C.]]
[[Category: Lee WH]]
[[Category: Lee, W H.]]
[[Category: Pantic N]]
[[Category: Pantic, N.]]
[[Category: Schoch G]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sobott F]]
[[Category: Schoch, G.]]
[[Category: Soundararajan M]]
[[Category: Sobott, F.]]
[[Category: Sundstrom M]]
[[Category: Soundararajan, M.]]
[[Category: Turnbull A]]
[[Category: Sundstrom, M.]]
[[Category: Ugochukwu E]]
[[Category: Turnbull, A.]]
[[Category: Weigelt J]]
[[Category: Ugochukwu, E.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: GDP]]
[[Category: gdp]]
[[Category: gem]]
[[Category: inactive state]]
[[Category: rgk family]]
[[Category: sgc]]
[[Category: small gtpase]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:00:04 2008''

Latest revision as of 12:35, 30 August 2023

Crystal structure of the human small GTPase GEMCrystal structure of the human small GTPase GEM

Structural highlights

2g3y is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GEM_HUMAN Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2g3y, resolution 2.40Å

Drag the structure with the mouse to rotate

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