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==Crystal structure of Pyrococcus furiosus PbaA, an archaeal homolog of proteasome-assembly chaperone==
==Crystal structure of Pyrococcus furiosus PbaA, an archaeal homolog of proteasome-assembly chaperone==
<StructureSection load='3wz2' size='340' side='right' caption='[[3wz2]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='3wz2' size='340' side='right'caption='[[3wz2]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3wz2]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WZ2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3wz2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WZ2 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vr0|3vr0]], [[3gaa|3gaa]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wz2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wz2 RCSB], [http://www.ebi.ac.uk/pdbsum/3wz2 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wz2 OCA], [https://pdbe.org/3wz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3wz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wz2 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q8U4Q9_PYRFU Q8U4Q9_PYRFU]
Formation of the eukaryotic proteasome is not a spontaneous process but a highly ordered process assisted by several assembly chaperones. In contrast, archaeal proteasome subunits can spontaneously assemble into an active form. Recent bioinformatic analysis identified the proteasome-assembly chaperone-like proteins, PbaA and PbaB, in archaea. Our previous study showed that the PbaB homotetramer functions as a proteasome activator through its tentacle-like C-terminal segments. However, a functional role of the other homolog PbaA has remained elusive. Here we determined the 2.25-A resolution structure of PbaA, illustrating its disparate tertiary and quaternary structures compared with PbaB. PbaA forms a homopentamer in which the C-terminal segments, with a putative proteasome-activating motif, are packed against the core. These findings offer deeper insights into the molecular evolution relationships between the proteasome-assembly chaperones and the proteasome activators.
 
Crystal structure of archaeal homolog of proteasome-assembly chaperone PbaA.,Sikdar A, Satoh T, Kawasaki M, Kato K Biochem Biophys Res Commun. 2014 Oct 5. pii: S0006-291X(14)01751-3. doi:, 10.1016/j.bbrc.2014.09.114. PMID:25285636<ref>PMID:25285636</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kato, K]]
[[Category: Large Structures]]
[[Category: Kawasaki, M]]
[[Category: Pyrococcus furiosus DSM 3638]]
[[Category: Satoh, T]]
[[Category: Kato K]]
[[Category: Sikdar, A]]
[[Category: Kawasaki M]]
[[Category: Chaperone]]
[[Category: Satoh T]]
[[Category: Proteasome]]
[[Category: Sikdar A]]
[[Category: Proteasome activator]]
[[Category: Proteasome assembly chaperone]]

Latest revision as of 11:48, 20 March 2024

Crystal structure of Pyrococcus furiosus PbaA, an archaeal homolog of proteasome-assembly chaperoneCrystal structure of Pyrococcus furiosus PbaA, an archaeal homolog of proteasome-assembly chaperone

Structural highlights

3wz2 is a 5 chain structure with sequence from Pyrococcus furiosus DSM 3638. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.25Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8U4Q9_PYRFU

3wz2, resolution 2.25Å

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