2wf0: Difference between revisions
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== | |||
<StructureSection load='2wf0' size='340' side='right' caption='[[2wf0]], [[Resolution|resolution]] 1.60Å' scene=''> | ==Human BACE-1 in complex with 4-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide== | ||
<StructureSection load='2wf0' size='340' side='right'caption='[[2wf0]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wf0]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2wf0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WF0 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY0:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-4-ETHYL-8-(2-OXOPYRROLIDIN-1-YL)QUINOLINE-6-CARBOXAMIDE'>ZY0</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZY0:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-4-ETHYL-8-(2-OXOPYRROLIDIN-1-YL)QUINOLINE-6-CARBOXAMIDE'>ZY0</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf0 OCA], [https://pdbe.org/2wf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2wf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf0 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf0_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf0_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wf0 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2wf0" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Beta secretase|Beta secretase]] | *[[Beta secretase 3D structures|Beta secretase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Charrier N]] | |||
[[Category: Charrier | [[Category: Clarke B]] | ||
[[Category: Clarke | [[Category: Cutler L]] | ||
[[Category: Cutler | [[Category: Demont E]] | ||
[[Category: Demont | [[Category: Dingwall C]] | ||
[[Category: Dingwall | [[Category: Dunsdon R]] | ||
[[Category: Dunsdon | [[Category: Hawkins J]] | ||
[[Category: Hawkins | [[Category: Howes C]] | ||
[[Category: Howes | [[Category: Hubbard J]] | ||
[[Category: Hubbard | [[Category: Hussain I]] | ||
[[Category: Hussain | [[Category: Maile G]] | ||
[[Category: Maile | [[Category: Matico R]] | ||
[[Category: Matico | [[Category: Mosley J]] | ||
[[Category: Mosley | [[Category: Naylor A]] | ||
[[Category: Naylor | [[Category: O'Brien A]] | ||
[[Category: Redshaw | [[Category: Redshaw S]] | ||
[[Category: Rowland | [[Category: Rowland P]] | ||
[[Category: Smith | [[Category: Smith KJ]] | ||
[[Category: Soleil | [[Category: Soleil V]] | ||
[[Category: Sweitzer | [[Category: Sweitzer S]] | ||
[[Category: Theobald | [[Category: Theobald P]] | ||
[[Category: Vesey | [[Category: Vesey D]] | ||
[[Category: Walter | [[Category: Walter DS]] | ||
[[Category: Wayne | [[Category: Wayne G]] | ||