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==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation H309S, crystallized with 2',3-(SP)-Cyclic-AMPS==
==Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation H309S, crystallized with 2',3-(SP)-Cyclic-AMPS==
<StructureSection load='2ypc' size='340' side='right' caption='[[2ypc]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
<StructureSection load='2ypc' size='340' side='right'caption='[[2ypc]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ypc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YPC FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ypc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QQX:[(3AR,4R,6R,6AR)-4-(6-AMINOPURIN-9-YL)-2-OXIDANYL-2-SULFANYLIDENE-3A,4,6,6A-TETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-6-YL]METHANOL'>QQX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.894&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xmi|2xmi]], [[2y1p|2y1p]], [[2y3x|2y3x]], [[2ydb|2ydb]], [[2ydc|2ydc]], [[2ydd|2ydd]], [[2yoz|2yoz]], [[2yp0|2yp0]], [[2ype|2ype]], [[2yph|2yph]], [[2yq9|2yq9]], [[3zbr|3zbr]], [[3zbs|3zbs]], [[3zbz|3zbz]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QQX:[(3AR,4R,6R,6AR)-4-(6-AMINOPURIN-9-YL)-2-OXIDANYL-2-SULFANYLIDENE-3A,4,6,6A-TETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-6-YL]METHANOL'>QQX</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2',3'-cyclic-nucleotide_3'-phosphodiesterase 2',3'-cyclic-nucleotide 3'-phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.37 3.1.4.37] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ypc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypc OCA], [https://pdbe.org/2ypc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ypc RCSB], [https://www.ebi.ac.uk/pdbsum/2ypc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ypc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ypc RCSB], [http://www.ebi.ac.uk/pdbsum/2ypc PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE]] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>
[https://www.uniprot.org/uniprot/CN37_MOUSE CN37_MOUSE] May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.<ref>PMID:22393399</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2ypc" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 2',3'-cyclic-nucleotide 3'-phosphodiesterase]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Han, H]]
[[Category: Han H]]
[[Category: Kursula, P]]
[[Category: Kursula P]]
[[Category: Lehtimaki, M]]
[[Category: Lehtimaki M]]
[[Category: Myllykoski, M]]
[[Category: Myllykoski M]]
[[Category: Raasakka, A]]
[[Category: Raasakka A]]
[[Category: Hydrolase]]
[[Category: Myelin]]
[[Category: Nervous system]]

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